Reactome | KDM1A [nucleoplasm]

KDM1A [nucleoplasm]

Stable Identifier

R-HSA-996769

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Lysine-specific histone demethylase 1A, KDM1A_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q96BD6 SPSB1

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External Reference Information

External Reference

UniProt:O60341 KDM1A

Gene Names

KDM1A, AOF2, KDM1, KIAA0601, LSD1

Chain

chain:1-852

Reference Genes

COSMIC (genes):KDM1A KDM1A

dbSNP Gene:23028 KDM1A

ENSEMBL:ENSG00000004487 KDM1A

Participates

as a member of

as an input of

as an output of

as a component of

Inferred To

FMS1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of KDM1A [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of KDM1A [nucleoplasm] (Danio rerio)

KDM1A [nucleoplasm] (Bos taurus)

KDM1A [nucleoplasm] (Canis familiaris)

KDM1A [nucleoplasm] (Drosophila melanogaster)

KDM1A [nucleoplasm] (Gallus gallus)

KDM1A [nucleoplasm] (Mus musculus)

KDM1A [nucleoplasm] (Rattus norvegicus)

KDM1A [nucleoplasm] (Schizosaccharomyces pombe)

KDM1A [nucleoplasm] (Sus scrofa)

KDM1A [nucleoplasm] (Xenopus tropicalis)

Interactors (119)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UKL0 RCOR1	1	RCOR1 [nucleoplasm] (R-HSA-996766)	0.897	9
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.855	12
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.837	9
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.835	33
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.788	7
UniProt:Q9NP66 HM20A			0.725	5
ChEBI:16238 FAD			0.702	3
UniProt:Q9Y466 NR2E1	1	NR2E1 [nucleoplasm] (R-HSA-376207)	0.681	7
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.667	3
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.666	4
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.666	4
UniProt:Q2M3C6 TM266			0.666	4
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.666	4
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.666	4
UniProt:Q9BUZ4 TRAF4			0.666	4
UniProt:Q8N6V9 TEX9			0.666	4
UniProt:Q8N0Z3 SPICE			0.666	4
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.658	3
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.649	4
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.641	4
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.632	6
UniProt:Q8IZ40 RCOR2			0.564	3
UniProt:Q92618 ZN516			0.558	6
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.558	8
UniProt:Q9BYF1 ACE2	5	glycosylated-ACE2 [plasma membrane] (R-HSA-9683480) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) ACE2(18-805) [plasma membrane] (R-HSA-2022344)	0.557	19
UniProt:P38432 COIL			0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:Q9P2K3-2 RCOR3			0.556	6
UniProt:Q9Y3C0 WASC3			0.556	3
UniProt:O75564-2 O755642			0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q8TF42 UBS3B			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.556	3
UniProt:Q86SG2 ANR23			0.556	3
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.556	3
UniProt:Q9BWT7 CAR10			0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.556	3
UniProt:Q9UPT5-1 EXOC7			0.556	3
UniProt:Q9H8W3 F204A			0.556	3
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.556	3
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.556	3
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.556	5
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.556	3
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.556	3
UniProt:Q3BBV0 NBPF1			0.556	5
UniProt:Q86WH2 RASF3			0.556	3
UniProt:O15060 ZBT39			0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q49A88-3 CCDC14			0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q6A163 KRT39	1	KRT39 [cytosol] (R-HSA-6809592)	0.556	3
UniProt:Q9NYA3 GOG6A			0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:Q96P16-3 RPRD1A			0.556	3
UniProt:Q86XR8-3 CEP57			0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q96F24 NRBF2			0.556	3
UniProt:Q9BYU1 PBX4			0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3
UniProt:P45379-11 P4537911			0.556	3
UniProt:P26378-2 P263782			0.556	3
UniProt:Q8TC20-4 CAGE1			0.556	3
UniProt:Q9HCM9 TRIM39	1	TRIM39 [cytosol] (R-HSA-5688971)	0.553	2
UniProt:Q13287 NMI	1	NMI [cytosol] (R-HSA-9731022)	0.553	2
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.547	4
UniProt:Q9P2K3 RCOR3			0.547	2
UniProt:P56545 CTBP2	1	CTBP2 [nucleoplasm] (R-HSA-5333990)	0.527	2
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.527	2
UniProt:Q9P0W2 HMG20B	1	HMG20B [nucleoplasm] (R-HSA-996745)	0.527	3
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.527	4
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.527	2
UniProt:Q9UHJ3 SMBT1			0.527	2
UniProt:Q9BTC8 MTA3	1	MTA3 [nucleoplasm] (R-HSA-4657013)	0.527	4
UniProt:P57682 KLF3			0.519	2
UniProt:Q9NS23 RASF1			0.508	2
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.508	2
UniProt:Q9BQS8 FYCO1			0.508	2
UniProt:Q03181 PPARD	1	PPARD [nucleoplasm] (R-HSA-446176)	0.508	2
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.508	2
UniProt:Q13133 NR1H3	1	NR1H3 [nucleoplasm] (R-HSA-8854957)	0.508	2
UniProt:Q8NEC7 GSTCD			0.508	2
UniProt:Q8IZU1 FAM9A			0.508	2
UniProt:Q6P047 CH074			0.508	2
UniProt:Q96H20 SNF8	1	SNF8 [cytosol] (R-HSA-917711)	0.508	2
UniProt:A5D8V7 ODAD3			0.508	2
UniProt:Q8TBB5 KLDC4			0.508	2
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.508	2
UniProt:O15198 SMAD9	3	SMAD9 [cytosol] (R-HSA-201478) p-S465,S467-SMAD9 [nucleoplasm] (R-HSA-201474) p-S465,S467-SMAD9 [cytosol] (R-HSA-201441)	0.508	2
UniProt:Q8IZS5 OFCC1			0.508	2
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.508	2
UniProt:Q99996 AKAP9	3	AKAP9(1-1118)-BRAF(381-766) fusion [cytosol] (R-HSA-6802267) AKAP9(1-1118)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802514) AKAP9 [cytosol] (R-HSA-380260)	0.508	2
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.508	2
UniProt:Q9BXL8 CDCA4			0.508	2
UniProt:Q9UGK8 SRGEF			0.508	2
UniProt:Q8N6K7 SAMD3			0.508	2
UniProt:Q8N4C7 STX19			0.508	2
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [extracellular region] (R-HSA-8863001) GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960)	0.508	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.508	2
UniProt:Q96JB6 LOXL4	3	LOXL4(25-?) [extracellular region] (R-HSA-2022087) LOXL4 [extracellular region] (R-HSA-2022127) LOXL4(?-756) [extracellular region] (R-HSA-2022098)	0.508	2
UniProt:Q96EY1 DNJA3			0.508	2
UniProt:P50749 RASF2			0.508	2
UniProt:Q9UBX0 HESX1			0.508	2
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.508	2
UniProt:Q96P16 RPRD1A	1	RPRD1A [nucleoplasm] (R-HSA-6814899)	0.502	2
UniProt:Q7Z4H7 HAUS6	1	HAUS6 [cytosol] (R-HSA-8855196)	0.502	2
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.502	2
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.499	4
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.484	3
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.484	3
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.483	2
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.462	5
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.462	5