Reactome | GATA1 [nucleoplasm]

GATA1 [nucleoplasm]

Stable Identifier

R-HSA-996772

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Erythroid transcription factor, GATA1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P15976 GATA1

Gene Names

GATA1, ERYF1, GF1

Chain

chain:1-413

Reference Genes

BioGPS Gene:2623 GATA1

COSMIC (genes):GATA1 GATA1

CTD Gene:2623 GATA1

dbSNP Gene:2623 GATA1

ENSEMBL:ENSG00000102145 GATA1

HGNC:4170 GATA1

KEGG:hsa:2623 GATA1

Monarch:2623 GATA1

NCBI Gene:2623 GATA1

OMIM:305371 GATA1

UCSC:P15976 GATA1

Reference Transcript

RefSeq:NM_002049.4 GATA1

Participates

as a member of

as a component of

GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)

Inferred To

gata1a [nucleoplasm] (Danio rerio)

elt-2 [nucleoplasm] (Caenorhabditis elegans)

Gata1 [nucleoplasm] (Mus musculus)

Gata1 [nucleoplasm] (Rattus norvegicus)

GATA1 [nucleoplasm] (Bos taurus)

GATA1 [nucleoplasm] (Canis familiaris)

GATA1 [nucleoplasm] (Sus scrofa)

gata1 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of GATA1 [nucleoplasm] (Gallus gallus)

grn [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_002040.1

ENSEMBL

ENSG00000102145, ENSP00000498550, ENSP00000365858, ENST00000651144, ENST00000376670

OpenTargets

ENSG00000102145

GeneCards

GATA1

HPA

ENSG00000102145-GATA1

PRO

P15976

Pharos - Targets

P15976

Orphanet

GATA1

PDB

6G0Q

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.582	6
UniProt:Q9H2U1 DHX36	1	DHX36 [cytosol] (R-HSA-3134862)	0.569	4
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:O43791 SPOP	3	SPOP [cytosol] (R-HSA-9929375) p-S6-SPOP [cytosol] (R-HSA-9929374) SPOP [nucleoplasm] (R-HSA-5635035)	0.553	6
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.508	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.471	2

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