Reactome | SH2B1 [cytosol]

SH2B1 [cytosol]

Stable Identifier

R-HSA-997253

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SH2B adapter protein 1, SH2B1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NRF2 SH2B1

Gene Names

SH2B1, KIAA1299, SH2B

Chain

chain:1-756

Reference Genes

ENSEMBL:ENSG00000178188 SH2B1

Participates

as a member of

SH2B family [cytosol] (Homo sapiens)

Inferred To

sh2b1 [cytosol] (Danio rerio)

Sh2b1 [cytosol] (Mus musculus)

Sh2b1 [cytosol] (Rattus norvegicus)

Lnk [cytosol] (Drosophila melanogaster)

SH2B1 [cytosol] (Bos taurus)

SH2B1 [cytosol] (Canis familiaris)

SH2B1 [cytosol] (Gallus gallus)

SH2B1 [cytosol] (Sus scrofa)

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.773	4
UniProt:O60674 JAK2	8	JAK2 [cytosol] (R-HSA-210620) p-Y1007-JAK2 [cytosol] (R-HSA-873799) p-12Y-JAK2 [cytosol] (R-HSA-2586516) JAK2 [endosome lumen] (R-HSA-2002372) JAK2 V617F [nucleoplasm] (R-HSA-5211269) p-Y813-JAK2 [cytosol] (R-HSA-997248) p-JAK2 [cytosol] (R-HSA-210621) p-Y1007,Y1008-JAK2 [cytosol] (R-HSA-9005327)	0.527	2
UniProt:P52631 Stat3	12	phospho-Stat3 [nucleoplasm] (R-RNO-8983188) phospho-Stat3 [cytosol] (R-RNO-8982823) phospho-Stat3 [nucleoplasm] (R-RNO-9701435) phospho-Stat3 [nucleoplasm] (R-RNO-9701429) phospho-Stat3 [nucleoplasm] (R-RNO-9027589) Phospho-STAT3 [cytosol] (R-RNO-198649) Signal transducer and activator of transcription 3 [cytosol] (R-RNO-198734) phospho-Stat3 [cytosol] (R-RNO-539048) phospho-Stat3 [cytosol] (R-RNO-8983130) Stat3 [cytosol] (R-RNO-539044) phospho-Stat3 [cytosol] (R-RNO-914048) phospho-Stat3 [nucleoplasm] (R-RNO-1112554)	0.471	2

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