Dephosphorylation of TYK2 by PTP1B

Stable Identifier
R-HSA-997311
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dephosphorylation of TYK2 by PTP1B
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TYK2 bears the substrate recognition motif for PTP1B, and on IFN stimulation PTP1B interacts with and dephosphorylates TYK2.
Literature References
PubMed ID Title Journal Year
11694501 TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

Horvath, CM, Cheng, A, Myers, MP, Barford, D, Tremblay, ML, Salmeen, A, Parisien, JP, Andersen, JN, Tonks, NK

J Biol Chem 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine phosphatase activity of PTPN1 [cytosol]

Physical Entity
PTPN1 [cytosol] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Orthologous Events
Dephosphorylation of TYK2 by PTP1B (Bos taurus)
Dephosphorylation of TYK2 by PTP1B (Canis familiaris)
Dephosphorylation of TYK2 by PTP1B (Gallus gallus)
Dephosphorylation of TYK2 by PTP1B (Mus musculus)
Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)
Dephosphorylation of TYK2 by PTP1B (Sus scrofa)
Dephosphorylation of TYK2 by PTP1B (Xenopus tropicalis)
Authored
Garapati, P V  (2010-07-07)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-11-09)
Cite Us!