Reactome | phospho-Sh2b2 [cytosol]

phospho-Sh2b2 [cytosol]

Stable Identifier

R-MMU-112184

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-Y629-SH2B2, Q9JID9

Locations in the PathwayBrowser

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Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by SCF-KIT (Mus musculus)
    - Regulation of KIT signaling (Mus musculus)
      - Phosphorylation of APS (Mus musculus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-APS dimer [cytosol] (Mus musculus)
        
        phospho-Sh2b2 [cytosol] (Mus musculus)
      - Recruitment of CBL to KIT (Mus musculus)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-APS dimer [cytosol] (Mus musculus)
        
        phospho-Sh2b2 [cytosol] (Mus musculus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-APS dimer [cytosol] (Mus musculus)
        
        phospho-Sh2b2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9JID9

Gene Names

Sh2b2

Reference Genes

BioGPS Gene:23921 Sh2b2

ENSEMBL:ENSMUSG00000005057

KEGG:mmu:23921 Sh2b2

Monarch:23921 Sh2b2

NCBI Gene:23921 Sh2b2

UCSC:Q9JID9 Sh2b2

Reference Transcript

Other Identifiers

10534585

1450718_at

1453389_a_at

17453714

23921

4398903

4662169

4683642

4704685

4739612

4779690

4790845

4810744

4855615

4885520

4945776

4955397

4984910

5057183

5081812

5140426

5150542

5176487

5232549

5259296

5279864

5448378

5553459

5586032

5616279

A_51_P404023

A_66_P113490

GE37226

GO:0001725

GO:0001726

GO:0001922

GO:0002376

GO:0005068

GO:0005515

GO:0005737

GO:0005829

GO:0005884

GO:0005886

GO:0007010

GO:0007165

GO:0007399

GO:0008286

GO:0019221

GO:0019222

GO:0030036

GO:0030154

GO:0035556

GO:0035591

GO:0042169

GO:0042593

GO:0042802

GO:0046323

GO:0046325

GO:0046578

GO:0048856

GO:0050776

GO:0050851

GO:0050853

GO:0050873

GO:0051649

GO:0055085

GO:0060090

ILMN_1258314

ILMN_2763206

mMC018182

Participates

as a component of

p-APS dimer [cytosol] (Mus musculus)

Other forms of this molecule

Sh2b2 [cytosol]

Inferred From

p-Y629-SH2B2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 629 (in Homo sapiens)

Coordinate

629

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001289867.1, XP_006504483.2, XP_006504485.1, NP_001289868.1, NP_061295.2

ENSEMBL

ENSMUSP00000005188, ENSMUST00000005188, ENSMUSP00000142398, ENSMUST00000196397

PRO

Q9JID9

MGI

1345171

PDB

1V5M

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q61851	4	FGFR3c [plasma membrane] (R-MMU-189913) FGFR3b [plasma membrane] (R-MMU-189911) phospho-p-6Y-FGFR3b [plasma membrane] (R-MMU-190384) phospho-p-6Y-FGFR3c [plasma membrane] (R-MMU-190382)	0.556	3

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