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Go!
CHEK1 [nucleoplasm]
Stable Identifier
R-MMU-113826
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
O35280
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
G2/M Checkpoints (Mus musculus)
Activation of ATR in response to replication stress (Mus musculus)
Recruitment and activation of Chk1 (Mus musculus)
CHEK1 [nucleoplasm] (Mus musculus)
G2/M DNA damage checkpoint (Mus musculus)
Recruitment and activation of Chk1 (Mus musculus)
CHEK1 [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
Homology Directed Repair (Mus musculus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
Processing of DNA double-strand break ends (Mus musculus)
Activation of CHEK1 at resected DNA DSBs (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
CHEK1 [nucleoplasm] (Mus musculus)
CHEK1 is recruited to resected DNA DSBs (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
CHEK1 [nucleoplasm] (Mus musculus)
CHEK1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:O35280
Reference Genes
BioGPS Gene:12649
ENSEMBL:ENSMUSG00000032113
ENSEMBL:ENSMUSG00000032113.17
KEGG Gene (Mus musculus):12649
Monarch:12649
NCBI Gene:12649
UCSC:O35280
Reference Transcript
RefSeq:NM_007691.5
Other Identifiers
103064_at
10592201
12649
1439208_at
1449708_s_at
1450677_at
17525503
4371287
4433960
4438921
4473964
4556351
4559221
4843644
4860701
4869126
4887838
4997544
5063104
5106956
5178247
5200545
5226930
5318248
5332418
5407263
5459614
5537733
AF016583_at
AF016583_g_at
A_51_P326499
A_55_P2000187
A_55_P2616463
GE34849
GO:0000077
GO:0000086
GO:0000166
GO:0000228
GO:0000278
GO:0000781
GO:0000785
GO:0000794
GO:0001833
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006281
GO:0006310
GO:0006325
GO:0006338
GO:0006468
GO:0006915
GO:0006974
GO:0006997
GO:0007010
GO:0007049
GO:0007095
GO:0010468
GO:0010569
GO:0010972
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0018107
GO:0019904
GO:0023052
GO:0032991
GO:0035402
GO:0035556
GO:0036211
GO:0042127
GO:0042770
GO:0043226
GO:0043231
GO:0044818
GO:0045787
GO:0045814
GO:0045839
GO:0046602
GO:0048856
GO:0071260
GO:0071310
GO:0071313
GO:0106310
GO:0140014
GO:0140096
GO:1902742
GO:2000279
ILMN_2630974
ILMN_2666965
ILMN_3009652
mMC008043
Participates
as an input of
Recruitment and activation of Chk1 (Mus musculus)
CHEK1 is recruited to resected DNA DSBs (Mus musculus)
as a component of
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
Other forms of this molecule
CHEK1 [cytosol]
phospho-p-S317,S345-CHEK1 [nucleoplasm]
Inferred From
CHEK1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_031717.2
Ensembl
ENSMUST00000172702
,
ENSMUSP00000034625
,
ENSMUST00000034625
,
ENSMUSG00000032113
,
ENSMUSP00000134388
PRO
O35280
MGI
1202065
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