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Socs3 [cytosol]
Stable Identifier
R-MMU-1169197
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Suppressor of cytokine signaling 3, SOCS3_MOUSE, Socs3
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
Polyubiquitination of substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
Release of E3 from polyubiquitinated substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Interferon alpha/beta signaling (Mus musculus)
Activation of JAK kinases (Mus musculus)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Mus musculus)
p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
Interferon gamma signaling (Mus musculus)
Regulation of IFNG signaling (Mus musculus)
SOCS-1 and SOCS-3 binds to p-JAK2 (Mus musculus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
Transphosphorylation of JAK1 (Mus musculus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
Signaling by CSF3 (G-CSF) (Mus musculus)
Inactivation of CSF3 (G-CSF) signaling (Mus musculus)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Mus musculus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-6 family signaling (Mus musculus)
Interleukin-6 signaling (Mus musculus)
SOCS3 binds IL6ST (Mus musculus)
Socs3 [cytosol] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Neddylation (Mus musculus)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
NEDD8-CRL5 E3 ligase [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
NEDD8-CRL5 E3 ligase [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
Signaling by PTK6 (Mus musculus)
PTK6 Activates STAT3 (Mus musculus)
SOCS3 binds activated PTK6 (Mus musculus)
Socs3 [cytosol] (Mus musculus)
p-Y342-PTK6:SOCS3 [cytosol] (Mus musculus)
Socs3 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O35718 Socs3
Gene Names
Socs3, Cis3, Cish3
Chain
chain:1-225
Reference Genes
BioGPS Gene:12702 Socs3
KEGG:mmu:12702 Socs3
Monarch:12702 Socs3
NCBI Gene:12702 Socs3
UCSC:O35718 Socs3
Reference Transcript
RefSeq:NM_007707.3 Socs3
RefSeq:XM_011248707.2 Socs3
Other Identifiers
10393449
111736_at
12702
1416576_at
1455899_x_at
1456212_x_at
17272619
4365695
4488499
4495025
4541101
4584825
4962124
5014820
5038130
5128935
5192231
5210624
5214476
92232_at
A_51_P474459
GE33504
GO:0001784
GO:0001932
GO:0003723
GO:0005515
GO:0005829
GO:0005942
GO:0006629
GO:0007165
GO:0007259
GO:0009898
GO:0009968
GO:0016567
GO:0030154
GO:0030292
GO:0035198
GO:0035556
GO:0042532
GO:0045597
GO:0046426
GO:0046627
GO:0046854
GO:0046935
GO:0048856
GO:0050728
GO:0060670
GO:0060674
GO:0097398
GO:0098772
GO:1990830
ILMN_2618176
U88328_at
mMC010165
Participates
as an input of
Phosphorylated Lepr Binds Socs3 (Mus musculus)
SOCS3 binds IL6ST (Mus musculus)
SOCS3 binds activated PTK6 (Mus musculus)
as a member of
Socs [cytosol] (Mus musculus)
Socs1,3 [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Mus musculus)
SOCS-1 and SOCS-3 [cytosol] (Mus musculus)
as an output of
p-Y-Stat1,3,5 dimer enhances expression of Socs3 (Mus musculus)
Socs3 gene expression is inhibited by Runx1 (Mus musculus)
as a component of
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Mus musculus)
Lep:p-Lepr:p-Jak2:Socs3 [plasma membrane] (Mus musculus)
p-Y342-PTK6:SOCS3 [cytosol] (Mus musculus)
Inferred From
SOCS3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_011247009.1
,
NP_031733.1
ENSEMBL
ENSMUSP00000059129
,
ENSMUST00000054002
PRO
O35718
MGI
1201791
PDB
4GL9
,
2BBU
,
2JZ3
,
2HMH
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00560
4
phospho-Il6st [plasma membrane]
(R-MMU-8950439)
Il6st [extracellular region]
(R-MMU-1067653)
Il6st [plasma membrane]
(R-MMU-448453)
phospho-Il6st [plasma membrane]
(R-MMU-1112580)
0.747
6
UniProt:P35235 Ptpn11
5
p-Y546,Y584-Shp2 [cytosol]
(R-MMU-443116)
Ptpn11 [cytosol]
(R-MMU-210002)
PTPN11 [nucleoplasm]
(R-MMU-8937745)
PTPN11 [cytosol]
(R-MMU-162563)
phospho-p-Y542,Y580-PTPN11 [cytosol]
(R-MMU-162573)
0.462
2
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