Cleavage of Nodal proprotein

Stable Identifier
R-MMU-1181148
Type
Reaction [transition]
Species
Mus musculus
Compartment
extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cleavage of Nodal proprotein
Nodal proprotein can be cleaved extracellularly by either Furin or Pace4 (Constam and Robertson 1999, Beck et al. 2002). In cells cultured in vitro the Nodal co-receptor Cripto-1 recruits both Nodal proprotein and Furin or Pace4 to the cell surface (Blanchet et al. 2008).
Literature References
PubMed ID Title Journal Year
18772886 Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation

Minchiotti, G, Mesnard, D, Constam, DB, Klumperman, J, Baflast, S, Le Good, JA, Oorschot, V, Blanchet, MH

EMBO J 2008
9885250 Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases

Constam, DB, Robertson, EJ

J Cell Biol 1999
12447384 Extraembryonic proteases regulate Nodal signalling during gastrulation

Beck, S, Roy, K, Beermann, F, Constam, DB, Guzman, M, Le Good, JA, Ben Haim, N

Nat Cell Biol 2002
Participants
Input
Output
Catalyst Activity

serine-type endopeptidase activity of Furin and Pace4 [extracellular region]

Physical Entity
Furin and Pace4 [extracellular region] (Mus musculus)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Cleavage of NODAL proprotein (Homo sapiens)
Authored
May, B  (2011-01-23)
Reviewed
Peng, C  (2011-08-25)
Created
May, B  (2011-01-28)
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