Reactome | KMT2C [nucleoplasm]

KMT2C [nucleoplasm]

Stable Identifier

R-MMU-1183224

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Q8BRH4

Locations in the PathwayBrowser

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Gene expression (Transcription) (Mus musculus)

- Epigenetic regulation of gene expression (Mus musculus)
  - Formation of WDR5-containing histone-modifying complexes (Mus musculus)
    - Formation of the MLL3 complex (Mus musculus)
      - KMT2C [nucleoplasm] (Mus musculus)
      - MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
    - PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Mus musculus)
      - MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
      - PAXIP1:PAGR1:MLL3 complex:NCOA6:KDM6A [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX1 (Mus musculus)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Mus musculus)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Mus musculus)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        MLL3 complex [nucleoplasm] (Mus musculus)
        
        KMT2C [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8BRH4 Kmt2c

Gene Names

Kmt2c, Mll3

Chain

chain:1-4903

Participates

as an input of

Formation of the MLL3 complex (Mus musculus)

as a component of

MLL3 complex [nucleoplasm] (Mus musculus)

Other forms of this molecule

Kmt2c [nucleoplasm]

Inferred From

KMT2C [nucleoplasm] (Homo sapiens)

Cross References

PRO

Q8BRH4

MGI

2444959

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6NZQ4 Paxip1	2	Paxip1 [nucleoplasm] (R-MMU-5619398) Paxip1 [nucleoplasm] (R-MMU-5619395)	0.527	2

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