The Nodal Receptor binds Nodal ligands

Stable Identifier
R-MMU-1225898
Type
Reaction [binding]
Species
Mus musculus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
The Nodal Receptor binds Nodal ligands
Nodal homodimers and Nodal:Gdf1 heterodimers bind Activin/Nodal receptors containing Acvr1b or Acvr1c, Acvr2a or Acvr2b, and the EGF-CFC coreceptor Cripto or Cryptic.
Literature References
PubMed ID Title Journal Year
24798330 Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation

Fuerer, C, Nostro, MC, Constam, DB

J. Biol. Chem. 2014
18089557 Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal

Kelber, JA, Booker, EC, Gray, PC, Vale, WW, Shani, G

J Biol Chem 2008
18079174 Long-range action of Nodal requires interaction with GDF1

Hamada, H, Sakuma, R, Nakamura, T, Saijoh, Y, Tanaka, C

Genes Dev 2007
11485994 The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development

Jörnvall, H, Andersson, O, Minchiotti, G, Blokzijl, A, Persico, MG, Reissmann, E, Chang, C, Brivanlou, AH, Ibáñez, CF

Genes Dev 2001
15485907 ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse

Jörnvall, H, Andersson, O, Reissmann, E, Mehrkash, M, Ibáñez, CF

Mol Cell Biol 2004
11389842 Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms

Yeo, C, Whitman, M

Mol Cell 2001
Participants
Input
Output
Orthologous Events
The NODAL Receptor binds NODAL ligands (Homo sapiens)
Authored
May, B  (2011-02-14)
Reviewed
Peng, C  (2011-08-25)
Created
May, B  (2011-03-03)
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