Reactome | NRG1/2 [extracellular region]

NRG1/2 [extracellular region]

Stable Identifier

R-MMU-1227956

Type

Set [DefinedSet]

Species

Mus musculus

Compartment

extracellular region

Synonyms

Neuregulins NRG1 and NRG2

Locations in the PathwayBrowser

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Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - Negative regulation of the PI3K/AKT network (Mus musculus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
        
        PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        Activator:PI3K [plasma membrane] (Mus musculus)
        
        NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
        
        NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
        
        Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
    - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
      - Activator:PI3K [plasma membrane] (Mus musculus)
        
        NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
        
        NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
        
        Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - RAS GEFs promote RAS nucleotide exchange (Mus musculus)
        
        RAS GEFs [plasma membrane] (Mus musculus)
        
        GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
- Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by PTK6 (Mus musculus)
    - ERBB2 Activates PTK6 Signaling (Mus musculus)
      - Activated ERBB2 binds PTK6 (BRK) (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-ERBB2 heterodimers:PTK6 [plasma membrane] (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
      - ERBB2 promotes PTK6 autophosphorylation (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-ERBB2 heterodimers:PTK6 [plasma membrane] (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by ERBB2 (Mus musculus)
    - Downregulation of ERBB2 signaling (Mus musculus)
      - Downregulation of ERBB2:ERBB3 signaling (Mus musculus)
        
        RNF41 binds neuregulin-activated ERBB3 (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Mus musculus)
        
        Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        RNF41 ubiquitinates activated ERBB3 (Mus musculus)
        
        NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Mus musculus)
        
        Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Mus musculus)
        
        Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
      - MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-ERBB2 heterodimers:MATK [plasma membrane] (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
      - PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)
        
        Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] (Mus musculus)
        
        Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
    - ERBB2 Activates PTK6 Signaling (Mus musculus)
      - Activated ERBB2 binds PTK6 (BRK) (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-ERBB2 heterodimers:PTK6 [plasma membrane] (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
      - ERBB2 promotes PTK6 autophosphorylation (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-ERBB2 heterodimers:PTK6 [plasma membrane] (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
    - ERBB2 Regulates Cell Motility (Mus musculus)
      - MEMO1 binds RHOA:GTP:DIAPH1 (Mus musculus)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Mus musculus)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
      - Phosphorylated ERBB2 heterodimers bind MEMO1 (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
    - ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Mus musculus)
      - ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:ERBB3:ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
      - Ligand-Activated EGFR/ERBB3/ERBB4 [plasma membrane] (Mus musculus)
        
        NRG1/2:ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
    - ERBB3 binds neuregulins (Mus musculus)
      - NRG1/2 [extracellular region] (Mus musculus)
      - NRG1/2:ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
    - GRB7 events in ERBB2 signaling (Mus musculus)
      - GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-ERBB2:GRB7 [plasma membrane] (Mus musculus)
        
        Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
    - PI3K events in ERBB2 signaling (Mus musculus)
      - Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Mus musculus)
        
        NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
        
        NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
        
        Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
      - PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
        
        NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
        
        NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
        
        Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
    - SHC1 events in ERBB2 signaling (Mus musculus)
      - SHC1 phosphorylation by ERBB2 heterodimers (Mus musculus)
        
        SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
    - SRC family kinases phosphorylate ERBB2 (Mus musculus)
      - ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:ERBB3:ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
      - p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:ERBB3:p-Y877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
    - Trans-autophosphorylation of ERBB2 heterodimers (Mus musculus)
      - ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:ERBB3:ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
      - p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
    - Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Mus musculus)
      - Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:p-10Y-ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
      - p-Y877-ERBB2 heterodimers [plasma membrane] (Mus musculus)
        
        NRG1/2:ERBB3:p-Y877-ERBB2 [plasma membrane] (Mus musculus)
        
        NRG1/2:ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
  - Signaling by ERBB4 (Mus musculus)
    - ERBB4 forms heterodimers with ERBB3 (Mus musculus)
      - ERBB4:ERBB3 heterodimer [plasma membrane] (Mus musculus)
        
        NRG1/2:ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)
      - NRG1/2:ERBB3 [plasma membrane] (Mus musculus)
        
        NRG1/2 [extracellular region] (Mus musculus)

Participants

members

Participates

as an input of

ERBB3 binds neuregulins (Mus musculus)

as a component of

Inferred From

NRG1/2 [extracellular region] (Homo sapiens)

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