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Hif1a [cytosol]
Stable Identifier
R-MMU-1234131
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
2xHP-HIF1A, Q61221
Locations in the PathwayBrowser for interactor UniProt:P40337 VHL
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to hypoxia (Mus musculus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Mus musculus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)
Hif1a [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q61221
Gene Names
Hif1a
Reference Genes
BioGPS Gene:15251 HIF1A
ENSEMBL:ENSMUSG00000021109
KEGG:mmu:15251 HIF1A
Monarch:15251 HIF1A
NCBI Gene:15251 HIF1A
UCSC:Q61221 HIF1A
Reference Transcript
RefSeq:NM_001313919.1 HIF1A
RefSeq:NM_001422143.1 HIF1A
RefSeq:NM_001313920.1 HIF1A
RefSeq:XM_017314961.1 HIF1A
RefSeq:NM_010431.3 HIF1A
Participates
as an output of
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)
as a member of
hydroxyPro-HIF-alpha [cytosol] (Mus musculus)
Other forms of this molecule
Hif1a [cytosol]
Hif1a [nucleoplasm]
Hif1a [cytosol]
phospho-Hif1a [cytosol]
phospho-Hif1a [cytosol]
Hif1a [nucleoplasm]
Inferred From
2xHP-HIF1A [cytosol]
(Homo sapiens)
Modified Residues
Name
monohydroxylated proline at 402 (in Homo sapiens)
Coordinate
402
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Name
monohydroxylated proline at 564 (in Homo sapiens)
Coordinate
564
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Cross References
RefSeq
NP_001300848.1
,
NP_001300849.1
,
NP_001409072.1
,
NP_034561.2
,
XP_017170450.1
ENSEMBL
ENSMUSG00000021109
,
ENSMUST00000021530
,
ENSMUSP00000021530
ZINC - Substances
HIF1A_MOUSE
ZINC target
Q61221
PRO
Q61221
MGI
106918
ZINC - Predictions - Purchasable
HIF1A_MOUSE
PDB
4ZPR
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53762 Arnt
2
Arnt [nucleoplasm]
(R-MMU-9621312)
Arnt [nucleoplasm]
(R-MMU-1234098)
0.723
6
UniProt:P25233 NECD
0.508
2
UniProt:P40337 VHL
3
VHL [cytosol]
(R-HSA-391423)
VHL [nucleoplasm]
(R-HSA-1234127)
monoSUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
0.499
3
UniProt:P35583 Foxa2
2
Foxa2 [nucleoplasm]
(R-MMU-187321)
Foxa2 [nucleoplasm]
(R-MMU-211275)
0.499
5
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.499
2
UniProt:P63166 Sumo1
8
lysyl-G97-Sumo1 [cytosol]
(R-MMU-9762259)
lysyl-G97-Sumo1 [nucleoplasm]
(R-MMU-9762260)
Ube2i-G97-Sumo1 [nucleoplasm]
(R-MMU-3730634)
Sumo1 [cytosol]
(R-MMU-4656941)
Sumo1 [nucleoplasm]
(R-MMU-2990831)
Sumo1 [nucleoplasm]
(R-MMU-877304)
Sumo1 [nucleoplasm]
(R-MMU-3730616)
Sumo1 [nucleoplasm]
(R-MMU-3730622)
0.463
6
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