Rora, Ep300, Ppargc1a bind Arntl (Bmal1) gene

Stable Identifier
R-MMU-1368101
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Rora, Ep300, Ppargc1a bind Arntl (Bmal1) gene

Rora binds the RRE DNA element and recruits the coactivators Pgc-1alpha (Ppargc1a) and p300 (Ep300, a histone acetyltransferase). Rora binds the promoter of the Arntl gene and enhances transcription.

Literature References
PubMed ID Title Journal Year
12152080 A transcription factor response element for gene expression during circadian night

Chen, W, Iino, M, Hayashi, S, Wakamatsu, H, Takasugi, T, Shigeyoshi, Y, Suzuki, Y, Sugano, S, Ueda, HR, Nakahama, K, Hashimoto, S, Nagano, M, Adachi, A

Nature 2002
17476214 Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism

Liu, T, Lin, JD, Li, S, Borjigin, J, Liu, C

Nature 2007
15199055 RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR

Parton, RG, Nixon, SJ, Lau, P, Muscat, GE

J Biol Chem 2004
15312651 A functional genomics strategy reveals Rora as a component of the mammalian circadian clock

Reyes, TM, Panda, S, Hogenesch, JB, Naik, KA, Sato, TK, Miraglia, LJ, FitzGerald, GA, Kay, SA, McNamara, P, Rudic, RD

Neuron 2004
15821743 The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1

Akashi, M, Takumi, T

Nat Struct Mol Biol 2005
16267379 Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors

Guillaumond, F, Giguère, V, Cermakian, N, Dardente, H

J Biol Rhythms 2005
15135064 Bidirectional role of orphan nuclear receptor RORalpha in clock gene transcriptions demonstrated by a novel reporter assay system

Honma, K, Honma, S, Nakajima, Y, Kimura, T, Ikeda, M, Ohmiya, Y

FEBS Lett 2004
Participants
Input
Output
Orthologous Events
RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene (Homo sapiens)
Authored
May, B  (2011-06-22)
Reviewed
Delaunay, F  (2012-01-28)
Created
May, B  (2011-06-30)
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