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BUB1B [cytosol]
Stable Identifier
R-MMU-141436
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q9Z1S0
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
Mitotic Spindle Checkpoint (Mus musculus)
Amplification of signal from the kinetochores (Mus musculus)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
Mad1:kinetochore complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Mad1:kinetochore complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
Mad1:kinetochore complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Mad1 binds kinetochore (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Mad1:kinetochore complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Release of activated MAD2 from kinetochores (Mus musculus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
Mad1:kinetochore complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Mad1:kinetochore complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Mus musculus)
Inactivation of APC/C via direct inhibition of the APC/C complex (Mus musculus)
Binding of the MCC complex to the APC/C complex (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Formation of the MCC complex (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
M Phase (Mus musculus)
Mitotic Metaphase and Anaphase (Mus musculus)
Mitotic Anaphase (Mus musculus)
Separation of Sister Chromatids (Mus musculus)
ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Separation of sister chromatids (Mus musculus)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Mitotic Prometaphase (Mus musculus)
EML4 and NUDC in mitotic spindle formation (Mus musculus)
EML4 recruits NUDC to mitotic spindle (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Kinetochore capture of astral microtubules (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Resolution of Sister Chromatid Cohesion (Mus musculus)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Kinetochore assembly (Mus musculus)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Regulation of mitotic cell cycle (Mus musculus)
APC/C-mediated degradation of cell cycle proteins (Mus musculus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Mus musculus)
APC-Cdc20 mediated degradation of Nek2A (Mus musculus)
Association of Nek2A with MCC:APC/C (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Degradation of multiubiquitinated Nek2A (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Multiubiquitinated Nek2A [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Multiubiquitination of Nek2A (Mus musculus)
Multiubiquitinated Nek2A [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Mus musculus)
Association of Cyclin A with the APC/C (Mus musculus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Degradation multiubiquitinated Cyclin A (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Mus musculus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Mus musculus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Mus musculus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
hBUBR1:hBUB3:MAD2* complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Regulation of APC/C activators between G1/S and early anaphase (Mus musculus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Mus musculus)
Inactivation of APC/C via direct inhibition of the APC/C complex (Mus musculus)
Binding of the MCC complex to the APC/C complex (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Formation of the MCC complex (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate Formins (Mus musculus)
AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
BUB1B [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9Z1S0
Reference Genes
BioGPS Gene:12236
ENSEMBL:ENSMUSG00000040084
ENSEMBL:ENSMUSG00000040084.10
KEGG Gene (Mus musculus):12236
Monarch:12236
NCBI Gene:12236
UCSC:Q9Z1S0
Reference Transcript
RefSeq:NM_009773.3
Other Identifiers
10474769
109165_at
12236
1416961_at
1447363_s_at
17374569
4370772
4396277
4486931
4494951
4525208
4541935
4597947
4692347
4781801
4781940
4831756
4849563
4981113
5017803
5233164
5257652
5272888
5308631
5375958
5426713
5435397
5466594
5516062
5574589
5576511
5577793
A_51_P490509
GE35128
GO:0000166
GO:0000278
GO:0000775
GO:0000776
GO:0000940
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005694
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0006468
GO:0006915
GO:0007049
GO:0007059
GO:0007091
GO:0007094
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0022414
GO:0023052
GO:0033597
GO:0036211
GO:0043226
GO:0048471
GO:0051301
GO:0051754
GO:0071459
GO:0106310
GO:0140013
GO:0140014
GO:0140096
ILMN_2774007
ILMN_2985969
mMC012156
Participates
as a component of
hBUBR1:hBUB3:MAD2* complex [cytosol] (Mus musculus)
Mitotic checkpoint complex [cytosol] (Mus musculus)
as an input of
Formation of the MCC complex (Mus musculus)
Inferred From
BUB1B [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_033903.2
Ensembl
ENSMUST00000038341
,
ENSMUSP00000037126
,
ENSMUSG00000040084
PRO
Q9Z1S0
MGI
1333889
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95071 UBR5
0.564
2
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.564
2
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.564
2
UniProt:Q9H1A4 ANAPC1
2
ANAPC1 [cytosol]
(R-HSA-174189)
ANAPC1 [nucleoplasm]
(R-HSA-174217)
0.564
2
UniProt:Q96DE5 ANAPC16
2
ANAPC16 [nucleoplasm]
(R-HSA-6805137)
ANAPC16 [cytosol]
(R-HSA-6805138)
0.564
2
UniProt:Q8NHZ8 CDC26
2
CDC26 [nucleoplasm]
(R-HSA-174216)
CDC26 [cytosol]
(R-HSA-174052)
0.564
2
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