Reactome | 14-3-3 sigma [cytosol]

14-3-3 sigma [cytosol]

Stable Identifier

R-MMU-1445092

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

14-3-3 protein sigma, Sfn, 1433S_MOUSE, Sfn

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - G2/M DNA damage checkpoint (Mus musculus)
      - Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Mus musculus)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        14-3-3 sigma dimer [cytosol] (Mus musculus)
        
        14-3-3 sigma [cytosol] (Mus musculus)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        14-3-3 sigma dimer [cytosol] (Mus musculus)
        
        14-3-3 sigma [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases activate PKNs (Mus musculus)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        14-3-3 sigma dimer [cytosol] (Mus musculus)
        
        14-3-3 sigma [cytosol] (Mus musculus)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        14-3-3 sigma dimer [cytosol] (Mus musculus)
        
        14-3-3 sigma [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:O70456 Sfn

Gene Names

Sfn, Mkrn3

Chain

chain:1-248

Reference Genes

BioGPS Gene:55948 Sfn

ENSEMBL:ENSMUSG00000047281.4 Sfn

KEGG Gene (Mus musculus):55948 Sfn

Monarch:55948 Sfn

NCBI Gene:55948 Sfn

UCSC:O70456 Sfn

Reference Transcript

RefSeq:NM_018754.2 Sfn

Other Identifiers

10517067

10572635

1448612_at

17431049

4638840

4706719

4781633

4840874

5371365

55948

96704_at

A_52_P334188

A_52_P334191

GO:0000122

GO:0001836

GO:0003334

GO:0005515

GO:0005576

GO:0005634

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006611

GO:0006886

GO:0006913

GO:0007005

GO:0007165

GO:0008630

GO:0010482

GO:0010737

GO:0010839

GO:0012501

GO:0019901

GO:0023052

GO:0030154

GO:0030216

GO:0030307

GO:0031424

GO:0042802

GO:0043226

GO:0043588

GO:0043616

GO:0045606

GO:0046827

GO:0048856

GO:0051219

GO:0051726

GO:0061436

GO:0072089

GO:2000647

ILMN_2648168

ILMN_2648169

Msa.5777.0_s_at

aa670807_s_at

mMC022352

Participates

as an input of

SFN dimerizes (Mus musculus)

as a component of

14-3-3 sigma dimer [cytosol] (Mus musculus)

Inferred From

SFN [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_061224.2

Ensembl

ENSMUSP00000050374, ENSMUSG00000047281, ENSMUST00000057311

PRO

O70456

MGI

1891831

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q61510	2	Trim25 [nucleoplasm] (R-MMU-5653667) Trim25 [cytosol] (R-MMU-918186)	0.526	3
UniProt:Q9QWL7	1	Krt17 [cytosol] (R-MMU-201583)	0.463	3

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