14-3-3 Binds Phosphorylated Tbc1d4 (AS160)

Stable Identifier
R-MMU-1445145
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytoplasmic vesicle membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
14-3-3 Binds Phosphorylated Tbc1d4 (AS160)
As160 (Tbc1d4) phosphorylated on serines 324, 348, 577, 595, and 758 and threonine 649 binds 14-3-3 proteins (Ramm et al. 2006, Ngo et al. 2009). Phosphorylation of As160 does not interfere with its interaction with Irap (Lnpep) (Peck et al. 2006).
Literature References
PubMed ID Title Journal Year
19013499 Reduced phosphorylation of AS160 contributes to glucocorticoid-mediated inhibition of glucose uptake in human and murine adipocytes

Barry, JB, Ngo, S, Prins, JB, Whitehead, JP, Nisbet, JC

Mol Cell Endocrinol 2009
16880201 A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160

James, DE, Guilhaus, M, Larance, M, Ramm, G

J Biol Chem 2006
16762977 Interaction of the Akt substrate, AS160, with the glucose transporter 4 vesicle marker protein, insulin-regulated aminopeptidase

Chai, SY, Macaulay, SL, Ye, S, Albiston, AL, Peck, GR, Fernando, RN, Pham, V

Mol Endocrinol 2006
Participants
Input
Output
Orthologous Events
14-3-3 binds p-5S,T642-AS160 (TBC1D4) (Homo sapiens)
Authored
May, B  (2011-07-07)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2011-07-13)
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