Akt Phosphorylates As160 (Tbc1d4)

Stable Identifier
R-MMU-1445150
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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Akt Phosphorylates As160 (Tbc1d4)

Akt2 and, to a lesser extent, Akt1 phosphorylate As160 (Tbc1d4) in response to insulin signaling (Hill et al. 1999, Kane et al. 2002, Bae et al. 2003, Jiang et al. 2003, Katome et al. 2003, Green et al. 2008, Ng et al. 2008, Gonzalez and McGraw 2009, Ng et al. 2010).

Literature References
PubMed ID Title Journal Year
18396141 Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes

Lopez, JA, James, DE, Ng, Y, Ramm, G

Cell Metab 2008
11994271 A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain

Garner, CC, Asara, JM, Lienhard, GE, Lane, WS, Sano, H, Liu, SC, Kane, S

J Biol Chem 2002
12734182 Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions

Matsushima, R, Kishi, K, Cantley, LC, Shiota, H, Katome, T, Ebina, Y, Gotoh, Y, Masuyama, N, Obata, T

J Biol Chem 2003
19372382 Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling

Gonzalez, E, McGraw, TE

Proc Natl Acad Sci U S A 2009
19897488 Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane

James, DE, Ng, Y, Coster, AC, Burchfield, JG, Stöckli, J, Ramm, G

J Biol Chem 2010
14522993 Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B

Mu, J, Birnbaum, MJ, Bae, SS, Cho, H

J Biol Chem 2003
18669636 Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

Kular, GS, Green, CJ, Leslie, NR, Sakamoto, K, Göransson, O, Alessi, DR, Gray, A, Hundal, HS

J Biol Chem 2008
12808134 Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

Chouinard, M, Jiang, ZY, Boese, Q, Czech, MP, Zhou, QL, Coleman, KA

Proc Natl Acad Sci U S A 2003
10523666 A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes

Macaulay, SL, James, DE, Clark, SF, Birnbaum, MJ, Hill, MM, Tucker, DF

Mol Cell Biol 1999
Participants
Catalyst Activity

protein serine/threonine kinase activity of p-T309, S474-Akt2 [plasma membrane]

protein serine/threonine kinase activity of p-T308,S473-Akt1 [plasma membrane]

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