Fusion of Glut4 Vesicle with the Plasma Membrane

Stable Identifier
Reaction [omitted]
Mus musculus
SVG |   | PPTX  | SBGN
Fusion of Glut4 Vesicle with the Plasma Membrane

After docking at the membrane Vamp2 on the vesicle interacts with Syntaxin-4 and Snap23 on the plasma membrane to catalyze fusion of the vesicle with the plasma membrane. Stxbp3 (Munc18c) bound to Stx4 prevents fusion until Stxbp3 is phosphorylated.

Literature References
PubMed ID Title Journal Year
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Endocrinology 2009
17515613 Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation

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Mol Cell Biol 2007
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Kawanishi, M, Tamori, Y, Okazawa, H, Araki, S, Shinoda, H, Kasuga, M

J Biol Chem 2000
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Toyoda, T, An, D, Witczak, CA, Koh, HJ, Hirshman, MF, Fujii, N, Goodyear, LJ

J Biol Chem 2011
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Yip, MF, Ramm, G, Larance, M, Hoehn, KL, Wagner, MC, Guilhaus, M, James, DE

Cell Metab 2008
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Bogan, JS, Hendon, N, McKee, AE, Tsao, TS, Lodish, HF

Nature 2003
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Bose, A, Robida, S, Furcinitti, PS, Chawla, A, Fogarty, K, Corvera, S, Czech, MP

Mol Cell Biol 2004
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Yu, C, Cresswell, J, Löffler, MG, Bogan, JS

J Biol Chem 2007
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Jewell, JL, Oh, E, Ramalingam, L, Kalwat, MA, Tagliabracci, VS, Tackett, L, Elmendorf, JS, Thurmond, DC

J. Cell Biol. 2011
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