Ampk-alpha2 Phosphorylates Tbc1d1

Stable Identifier
R-MMU-1454711
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
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Ampk-alpha2 Phosphorylates Tbc1d1

Ampk-alpha2 phosphorylates Tbc1d1 on serine-231 and probably other residues (Taylor et al. 2008, Peck et al. 2009, Pehmoller et al. 2009, Vichaiwong et al. 2010). Ampk-alpha2 is activated in response to muscle contraction and insulin signaling.

Literature References
PubMed ID Title Journal Year
19531644 Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

Wojtaszewski, JF, Richter, EA, Pehmøller, C, Chen, S, Hardie, DG, Birk, JB, Mackintosh, C, Treebak, JT

Am J Physiol Endocrinol Metab 2009
18276596 Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle

Feener, EP, An, D, Hirshman, MF, Goodyear, LJ, Xie, J, Bowles, N, Yu, H, Kramer, HF, Roeckl, KS, Fujii, NL, Taylor, EB

J Biol Chem 2008
20701589 Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle

An, D, Hirshman, MF, Goodyear, LJ, Vichaiwong, K, Jessen, N, Purohit, S, Toyoda, T

Biochem J 2010
19740738 Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation

Chavez, JA, Lienhard, GE, Lane, WS, Peck, GR, Budnik, BA, Zierath, JR, Roach, WG, Karlsson, HK

J Biol Chem 2009
Participants
Catalyst Activity

protein serine/threonine kinase activity of Ampk-alpha2:Ampk-beta:Ampk-gamma:AMP [cytosol]

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