Reactome | mFz8CRD [extracellular region]

mFz8CRD [extracellular region]

Stable Identifier

R-MMU-1458870

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

cysteine rich domain (CRD) of mFzd8 (engineered), extracellular domain mFz8 (engineered)

General

Produced in HEK293 cellsfor co-IP with hLRP6 from conditioned medium

Literature References

PubMed ID	Title	Journal	Year
11029007	LDL-receptor-related proteins in Wnt signal transduction Tamai, K, Semenov, M, Kato, Y, Spokony, R, Liu, C, Katsuyama, Y, Hess, F, Saint-Jeannet, JP, He, X	Nature	2000

External Reference Information

External Reference

UniProt:Q61091 Fzd8

Gene Names

Fzd8

Chain

signal peptide:1-27, chain:28-685

Reference Genes

BioGPS Gene:14370 Fzd8

ENSEMBL:ENSMUSG00000036904 Fzd8

KEGG Gene (Mus musculus):14370 Fzd8

Monarch:14370 Fzd8

NCBI Gene:14370 Fzd8

UCSC:Q61091 Fzd8

Reference Transcript

RefSeq:NM_008058.2 Fzd8

Other Identifiers

10453738

110015_at

1423348_at

14370

1445815_at

166437_f_at

17348276

4418857

4439496

4534995

4595142

4724423

4963064

5202021

5349189

5351727

5356916

5397527

5400270

5528333

5539143

5541997

5565322

99415_at

A_51_P312517

A_52_P676589

A_55_P2035804

GE34436

GO:0003674

GO:0004888

GO:0005515

GO:0005575

GO:0007165

GO:0007166

GO:0008150

GO:0016020

GO:0016021

ILMN_2597578

Msa.1894.0_at

Msa.1894.0_g_at

mMC019983

Participates

as a component of

mFzd8CRD:LRP6N [extracellular region] (Homo sapiens)

as an input of

mFz8CRD binds LRP6N in vitro (Homo sapiens)

Other forms of this molecule

Fzd8 [plasma membrane]

Cross References

RefSeq

NP_032084.2

Ensembl

ENSMUST00000041080, ENSMUSP00000039660, ENSMUSG00000036904

PRO

Q61091

MGI

108460

PDB

4F0A, 6TFM, 6AHY, 1IJY, 6TFB

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27467 Wnt3a	12	Wnt3a [endocytic vesicle membrane] (R-MMU-3781944) Wnt3a [extracellular exosome] (R-MMU-3781968) N4GlycoAsn-PalmS Wnt3a [extracellular region] (R-MMU-3769340) Wnt3a [extracellular region] (R-MMU-3772390) Wnt3a [early endosome membrane] (R-MMU-5368483) Wnt3a [endoplasmic reticulum lumen] (R-MMU-3238294) N4GlycoAsn-PalmS Wnt3a [endoplasmic reticulum lumen] (R-MMU-3238346) N-glycosyl Wnt3a [endoplasmic reticulum lumen] (R-MMU-3238233) Wnt3a [endoplasmic reticulum lumen] (R-MMU-3238344) Wnt3a [Golgi lumen] (R-MMU-3247832) Wnt3a [extracellular region] (R-MMU-3247784) Wnt3a [plasma membrane] (R-MMU-3247807)	0.713	3
UniProt:O75581 LRP6	8	p-S1490-LRP6 [plasma membrane] (R-HSA-206156) p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884) LRP6 [early endosome membrane] (R-HSA-5368481) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6N [extracellular region] (R-HSA-5334021) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) LRP6 [plasma membrane] (R-HSA-206252)	0.702	4
UniProt:P28026 wnt8	1	Wnt-8 [extracellular region] (R-XLA-517412)	0.618	3
UniProt:Q8BH60	3	Gopc [plasma membrane] (R-MMU-5626572) Gopc [lysosomal membrane] (R-MMU-5627281) Gopc [Golgi-associated vesicle membrane] (R-MMU-5627067)	0.581	3

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