GPCho is hydrolyzed to Cho and G3P by Gpcpd1

Stable Identifier
R-MMU-1483112
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
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GPCho is hydrolyzed to Cho and G3P by Gpcpd1
In mice in the cytosol, glycerophosphocholine phosphodiesterase (Gpcpd1, also known as Gde5) hydrolyzes glycerophosphocholine (GPCho) to produce choline (Cho) and glycerol-3-phosphate (G3P) (Ross et al. 1995, Yanaka 2007, Bachmann et al. 2006, Okazaki et al. 2010).
Literature References
PubMed ID Title Journal Year
17690467 Mammalian glycerophosphodiester phosphodiesterases

Yanaka, Noriyuki

Biosci Biotechnol Biochem 2007
16472945 Genomic organization, characterization, and molecular 3D model of GDE1, a novel mammalian glycerophosphoinositol phosphodiesterase

Mocz, G, Duennebier, FF, Bachmann, AS

Gene 2006
8614297 Multiple forms of the enzyme glycerophosphodiesterase are present in human brain

Kish, SJ, Sherwin, AL, Ross, BM

Lipids 1995
20576599 A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism

Shiro, Y, Yoshizawa, I, Ogawa, Y, Kamei, Y, Okazaki, Y, Izumi, T, Mariggiò, S, Wada, M, Corda, D, Fujioka, Y, Nogusa, Y, Kato, N, Okamoto, K, Ohshima, N, Yanaka, Noriyuki, Maeda, M

J Biol Chem 2010
Participants
Input
Output
Catalyst Activity

glycerophosphodiester phosphodiesterase activity of Gpcpd1 [cytosol]

Physical Entity
Gpcpd1 [cytosol] (Mus musculus)
Activity
glycerophosphodiester phosphodiesterase activity (GO:0008889)
Orthologous Events
GPCho is hydrolyzed to Cho and G3P by GPCPD1 (Homo sapiens)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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