Reactome | Upf3b [cytosol]

Upf3b [cytosol]

Stable Identifier

R-MMU-159258

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

UPF3B, Q3ULL6

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        UPF3 [cytosol] (Mus musculus)
        
        Upf3b [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        UPF3 [cytosol] (Mus musculus)
        
        Upf3b [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        UPF3 [cytosol] (Mus musculus)
        
        Upf3b [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        UPF3 [cytosol] (Mus musculus)
        
        Upf3b [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        UPF3 [cytosol] (Mus musculus)
        
        Upf3b [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        UPF3 [cytosol] (Mus musculus)
        
        Upf3b [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        UPF3 [cytosol] (Mus musculus)
        
        Upf3b [cytosol] (Mus musculus)
- Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
  - Transport of Mature Transcript to Cytoplasm (Mus musculus)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Mus musculus)
      - Transport of the export-competent mRNP complex through the NPC (Mus musculus)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Mus musculus)
        
        EJC [cytosol] (Mus musculus)
        
        Upf3b [cytosol] (Mus musculus)
      - mRNP complex dissociates from cytosolic face of NPC (Mus musculus)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Mus musculus)
        
        EJC [cytosol] (Mus musculus)
        
        Upf3b [cytosol] (Mus musculus)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Mus musculus)
        
        EJC [cytosol] (Mus musculus)
        
        Upf3b [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q3ULL6

Gene Names

Upf3b

Reference Genes

BioGPS Gene:68134 Upf3b

ENSEMBL:ENSMUSG00000036572

ENSEMBL:ENSMUSG00000036572.17 Upf3b

KEGG Gene (Mus musculus):68134 Upf3b

Monarch:68134 Upf3b

NCBI Gene:68134 Upf3b

UCSC:Q3ULL6 Upf3b

Reference Transcript

RefSeq:NM_026573.3 Upf3b

Other Identifiers

10604078

1434842_s_at

17541010

4494084

4530509

4592794

4702882

4762310

4773903

4795149

4888225

5010706

5119638

5195382

5199881

5271022

5308648

5400049

5549671

68134

93240_f_at

93241_r_at

A_51_P162649

A_51_P291139

A_52_P595162

A_55_P1963344

C80366_rc_at

GE1549058

GO:0000184

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005815

GO:0005829

GO:0005856

GO:0007420

GO:0016071

GO:0030154

GO:0031175

GO:0034451

GO:0035145

GO:0043025

GO:0043226

GO:0045666

GO:0045727

GO:0048856

GO:1905746

ILMN_1235376

ILMN_2494625

mMC004978

Participates

as a member of

UPF3 [cytosol] (Mus musculus)

as a component of

EJC [cytosol] (Mus musculus)

Other forms of this molecule

Upf3b [nucleoplasm]

Inferred From

UPF3B [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_080849.1

Ensembl

ENSMUST00000076265, ENSMUSG00000036572, ENSMUSP00000075614

MGI

1915384

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