Reactome | Trib3 [cytosol]

Trib3 [cytosol]

Stable Identifier

R-MMU-162411

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

TRIB3, Q8K4K2

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by Insulin receptor (Mus musculus)
    - Insulin receptor signalling cascade (Mus musculus)
      - IRS-mediated signalling (Mus musculus)
        
        PI3K Cascade (Mus musculus)
        
        Activation of AKT2 (Mus musculus)
        
        AKT2 binds PIP3 (Mus musculus)
        
        AKT2:THEM4,TRIB3 [cytosol] (Mus musculus)
        
        THEM4,TRIB3 [cytosol] (Mus musculus)
        
        Trib3 [cytosol] (Mus musculus)
        
        THEM4,TRIB3 [cytosol] (Mus musculus)
        
        Trib3 [cytosol] (Mus musculus)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
    - IGF1R signaling cascade (Mus musculus)
      - IRS-related events triggered by IGF1R (Mus musculus)
        
        IRS-mediated signalling (Mus musculus)
        
        PI3K Cascade (Mus musculus)
        
        Activation of AKT2 (Mus musculus)
        
        AKT2 binds PIP3 (Mus musculus)
        
        AKT2:THEM4,TRIB3 [cytosol] (Mus musculus)
        
        THEM4,TRIB3 [cytosol] (Mus musculus)
        
        Trib3 [cytosol] (Mus musculus)
        
        THEM4,TRIB3 [cytosol] (Mus musculus)
        
        Trib3 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8K4K2 Trib3

Gene Names

Trib3, Nipk, Trb3

Chain

chain:1-354

Reference Genes

BioGPS Gene:228775 Trib3

ENSEMBL:ENSMUSG00000032715 Trib3

KEGG Gene (Mus musculus):228775 Trib3

Monarch:228775 Trib3

NCBI Gene:228775 Trib3

UCSC:Q8K4K2 Trib3

Reference Transcript

RefSeq:NM_175093.2 Trib3

Other Identifiers

10488608

1426065_a_at

1456225_x_at

161067_at

17392925

228775

4740595

4814345

5048995

5171171

5194568

5196658

5280880

5423202

5589701

A_52_P600274

A_55_P2009988

C76863_rc_at

GE1442542

GO:0003674

GO:0003714

GO:0004672

GO:0005524

GO:0006464

GO:0006468

GO:0008150

GO:0009058

GO:0016301

GO:0034641

GO:0043167

ILMN_1225528

ILMN_1244279

ILMN_1252762

mMC013414

Participates

as a member of

THEM4,TRIB3 [cytosol] (Mus musculus)

Other forms of this molecule

Trib3 [nucleoplasm]

Trib3 [plasma membrane]

Inferred From

TRIB3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_780302.2

Ensembl

ENSMUSG00000032715, ENSMUST00000040312, ENSMUSP00000041747

PRO

Q8K4K2

MGI

1345675

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31750 Akt1	10	phospho-Akt1 [plasma membrane] (R-MMU-199430) p-T308,S473-Akt1 [plasma membrane] (R-MMU-1445123) p-T308,S473-Akt1 [cytosol] (R-MMU-162346) phospho-Akt1 [cytosol] (R-MMU-8848757) phospho-Akt1 [cytosol] (R-MMU-198634) phospho-Akt1 [nucleoplasm] (R-MMU-198357) Akt1 [cytosol] (R-MMU-58252) Akt1 [plasma membrane] (R-MMU-199416) phospho-Akt1 [plasma membrane] (R-MMU-377265) phospho-Akt1 [cytosol] (R-MMU-198356)	0.625	5
UniProt:Q06507 Atf4	1	Atf4 [nucleoplasm] (R-MMU-9635384)	0.508	3