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About
What is Reactome ?
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phospho-p-Y542,Y580-PTPN11 [cytosol]
Stable Identifier
R-MMU-162573
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P35235
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by CSF3 (G-CSF) (Mus musculus)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Mus musculus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-6 family signaling (Mus musculus)
Interleukin-6 signaling (Mus musculus)
PTPN11 is phosphorylated (Mus musculus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF-independent MAPK1/3 activation (Mus musculus)
MAPK1 (ERK2) activation (Mus musculus)
MAP2K2 binds MAPK1 (Mus musculus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
MAPK3 (ERK1) activation (Mus musculus)
MAP2K1 binds MAPK3 (Mus musculus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by FGFR (Mus musculus)
Signaling by FGFR1 (Mus musculus)
Downstream signaling of activated FGFR1 (Mus musculus)
FRS-mediated FGFR1 signaling (Mus musculus)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Mus musculus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
PI-3K cascade:FGFR1 (Mus musculus)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Negative regulation of FGFR1 signaling (Mus musculus)
CBL ubiquitinates FRS2 and FGFR1 (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Signaling by FGFR2 (Mus musculus)
Downstream signaling of activated FGFR2 (Mus musculus)
FRS-mediated FGFR2 signaling (Mus musculus)
Activated FGFR2 phosphorylates PPTN11 (Mus musculus)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
PI-3K cascade:FGFR2 (Mus musculus)
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Negative regulation of FGFR2 signaling (Mus musculus)
CBL ubiquitinates FRS2 and FGFR2 (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Signaling by FGFR3 (Mus musculus)
Downstream signaling of activated FGFR3 (Mus musculus)
FRS-mediated FGFR3 signaling (Mus musculus)
Activated FGFR3 phosphorylates PPTN11 (Mus musculus)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
PI-3K cascade:FGFR3 (Mus musculus)
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Negative regulation of FGFR3 signaling (Mus musculus)
CBL ubiquitinates FRS2 and FGFR3 (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Signaling by FGFR4 (Mus musculus)
Downstream signaling of activated FGFR4 (Mus musculus)
FRS-mediated FGFR4 signaling (Mus musculus)
Activated FGFR4 phosphorylates PPTN11 (Mus musculus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
PI-3K cascade:FGFR4 (Mus musculus)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Negative regulation of FGFR4 signaling (Mus musculus)
CBL ubiquitinates FRS2 and FGFR4 (Mus musculus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Mus musculus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
Activated FGFR bound to PI3K [cytosol] (Mus musculus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Mus musculus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Signaling by SCF-KIT (Mus musculus)
GRB2 is indirectly recruited to p-KIT through SHP2 (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Indirect recruitment of GAB2 to p-KIT (Mus musculus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Phosphorylation of GAB2 by SFKs (Mus musculus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Phosphorylation of SHP2 by SFKs (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
Activated FGFR bound to PI3K [cytosol] (Mus musculus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Mus musculus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P35235 Ptpn11
Gene Names
Ptpn11
Chain
initiator methionine:, chain:2-593
Reference Genes
BioGPS Gene:19247 Ptpn11
KEGG:mmu:19247 Ptpn11
Monarch:19247 Ptpn11
NCBI Gene:19247 Ptpn11
UCSC:P35235 Ptpn11
Reference Transcript
RefSeq:NM_011202.3 Ptpn11
RefSeq:NM_001109992.1 Ptpn11
Other Identifiers
102874_at
10533285
114636_at
1421196_at
1427699_a_at
1451225_at
17452161
19247
4322855
4329015
4478855
4507916
4518283
4524274
4566118
4618693
4664661
4849125
4891955
5199118
5200785
5319892
5406406
5431131
5469518
5614591
A_51_P173622
A_52_P211393
A_52_P641185
A_66_P101820
GE35963
GO:0000077
GO:0001784
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005158
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006470
GO:0006629
GO:0006641
GO:0007165
GO:0007173
GO:0007229
GO:0007409
GO:0007420
GO:0007507
GO:0008543
GO:0009755
GO:0009967
GO:0016311
GO:0016787
GO:0019901
GO:0019904
GO:0021697
GO:0022414
GO:0030154
GO:0030159
GO:0030220
GO:0030971
GO:0031748
GO:0032331
GO:0032480
GO:0032528
GO:0032728
GO:0032755
GO:0032760
GO:0032991
GO:0033628
GO:0033629
GO:0035264
GO:0035265
GO:0035335
GO:0035855
GO:0036302
GO:0038127
GO:0042445
GO:0042593
GO:0043226
GO:0043254
GO:0043274
GO:0043408
GO:0043560
GO:0044853
GO:0045296
GO:0045778
GO:0045931
GO:0046326
GO:0046628
GO:0046676
GO:0046825
GO:0046887
GO:0046888
GO:0048008
GO:0048011
GO:0048013
GO:0048806
GO:0048839
GO:0048856
GO:0048870
GO:0048873
GO:0050731
GO:0050839
GO:0051428
GO:0051463
GO:0051894
GO:0060020
GO:0060090
GO:0060125
GO:0060325
GO:0061582
GO:0070374
GO:0071260
GO:0071364
GO:0140096
GO:1990782
ILMN_1245874
ILMN_2681329
ILMN_2723559
ILMN_2743723
ILMN_3001598
d84372_s_at
mMC000988
mMC014708
mMC023487
mMR027502
Participates
as a component of
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Other forms of this molecule
p-Y546,Y584-Shp2 [cytosol]
Ptpn11 [cytosol]
PTPN11 [nucleoplasm]
PTPN11 [cytosol]
Inferred From
p-Y542,Y580-PTPN11 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 542 (in Homo sapiens)
Coordinate
542
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 580 (in Homo sapiens)
Coordinate
580
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_035332.1
,
NP_001103462.1
ENSEMBL
ENSMUST00000054547
,
ENSMUSP00000098333
,
ENSMUST00000100770
,
ENSMUSP00000058757
PRO
P35235
GlyGen
P35235
MGI
99511
PDB
1AYA
,
1AYB
,
1AYD
,
1AYC
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.809
7
UniProt:Q60631 Grb2
1
Grb2 [cytosol]
(R-MMU-443287)
0.59
3
UniProt:P97484
15
Lilrb3 [plasma membrane]
(R-MMU-197721-6)
Lilrb3 [plasma membrane]
(R-MMU-3006558-6)
Lilrb3 [plasma membrane]
(R-MMU-6786744-6)
Lilrb3 [plasma membrane]
(R-MMU-6786745-6)
Lilrb3 [plasma membrane]
(R-MMU-6786742-6)
Lilrb3 [plasma membrane]
(R-MMU-197730-6)
Lilrb3 [tertiary granule membrane]
(R-MMU-6801367-6)
Lilrb3 [tertiary granule membrane]
(R-MMU-6801392-6)
Lilrb3 [specific granule membrane]
(R-MMU-6801372-6)
Lilrb3 [plasma membrane]
(R-MMU-197727-6)
Lilrb3 [secretory granule membrane]
(R-MMU-6803281-6)
Lilrb3 [plasma membrane]
(R-MMU-197725-6)
Lilrb3 [plasma membrane]
(R-MMU-6786743-6)
Lilrb3 [ficolin-1-rich granule membrane]
(R-MMU-6801373-6)
Lilrb3 [ficolin-1-rich granule membrane]
(R-MMU-6801406-6)
0.589
2
UniProt:P30999 Ctnnd1
2
Ctnnd1 [plasma membrane]
(R-MMU-9761465)
Ctnnd1 [plasma membrane]
(R-MMU-418996)
0.544
3
UniProt:P10721 KIT
20
KIT C443Y [plasma membrane]
(R-HSA-9680045)
KIT T417_D419delinsY [plasma membrane]
(R-HSA-9680110)
KIT S476I [plasma membrane]
(R-HSA-9680090)
KIT K509I [plasma membrane]
(R-HSA-9680177)
KIT D419A [plasma membrane]
(R-HSA-9680051)
KIT D419del [plasma membrane]
(R-HSA-9680079)
KIT S501_A502dup [plasma membrane]
(R-HSA-9680105)
KIT D419G [plasma membrane]
(R-HSA-9680057)
KIT N505_F508dup [plasma membrane]
(R-HSA-9680085)
KIT C443S [plasma membrane]
(R-HSA-9680038)
KIT D419N [plasma membrane]
(R-HSA-9680071)
KIT S476N [plasma membrane]
(R-HSA-9680097)
KIT D419H [plasma membrane]
(R-HSA-9680066)
KIT V560_L576del [plasma membrane]
(R-HSA-9670336)
KIT Y823N [plasma membrane]
(R-HSA-9669591)
KIT Y823C [plasma membrane]
(R-HSA-9669585)
p6Y-KIT Y823D [plasma membrane]
(R-HSA-9669628)
p7Y-KIT D816V [plasma membrane]
(R-HSA-9669612)
p7Y-KIT K642E [plasma membrane]
(R-HSA-9669596)
p7Y-KIT N822K [plasma membrane]
(R-HSA-9669617)
0.524
2
UniProt:P28776
1
IDO1 [cytosol]
(R-MMU-198574)
0.499
5
UniProt:Q8K4V6 Q8K4V6
0.499
3
UniProt:P15209 Ntrk2
4
phospho-p-5Y-NTRK2 [plasma membrane]
(R-MMU-9026475)
Ntrk2 [plasma membrane]
(R-MMU-9025038)
p-5Y-Ntrk2 [plasma membrane]
(R-MMU-9030410)
p-5Y,S478-Ntrk2 [plasma membrane]
(R-MMU-9033310)
0.499
2
UniProt:Q6Q899 Rigi
4
PolyUb-DDX58 [cytosol]
(R-MMU-6782770)
Rig-I [cytosol]
(R-MMU-936468)
K63polyUb-DDX58 [cytosol]
(R-MMU-918191)
DDX58 [cytosol]
(R-MMU-168917)
0.462
4
UniProt:P35438 Grin1
3
Grin1 [plasma membrane]
(R-MMU-3928395)
Grin1 [endoplasmic reticulum membrane]
(R-MMU-9610359)
Grin1 [transport vesicle membrane]
(R-MMU-9610566)
0.462
2
UniProt:Q80ZE3
3
SIGLEC11 [plasma membrane]
(R-MMU-197709)
SIGLEC10 [plasma membrane]
(R-MMU-197707)
SIGLEC16 [plasma membrane]
(R-MMU-2326826)
0.462
4
UniProt:O35718 Socs3
1
Socs3 [cytosol]
(R-MMU-1169197)
0.462
2
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