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PAK1 [cytosol]
Stable Identifier
R-MMU-162629
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
O88643
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
EPHB-mediated forward signaling (Mus musculus)
PAK1 binds RAC1:GTP (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Ephrin signaling (Mus musculus)
PAK binds RAC and bPIX (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Mus musculus)
PAK1/3, 2 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1/3, 2 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAKs autophosphorylate (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Mus musculus)
PAK1/3, 2 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1/3, 2 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
L1CAM interactions (Mus musculus)
Signal transduction by L1 (Mus musculus)
Interaction of PAK1 with Rac1-GTP (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Semaphorin interactions (Mus musculus)
Sema3A PAK dependent Axon repulsion (Mus musculus)
Activation of PAK by Rac1 (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Autophosphorylation of PAK (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
CD28 co-stimulation (Mus musculus)
CD28 dependent Vav1 pathway (Mus musculus)
Activation of PAKs by RAC1 and CDC42 (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
TCR signaling (Mus musculus)
Generation of second messenger molecules (Mus musculus)
NCK binds PAK (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
p-SLP-76:NCK:PAK [cytosol] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CD209 (DC-SIGN) signaling (Mus musculus)
PAK phosphorylates p21 RAF1 on S338 (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated MAPK activation (Mus musculus)
Autophosphorylation of PAK (Mus musculus)
PAK dimer [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
PAK dimer [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Recruitment of PAK to the membrane by binding active RAC1 (Mus musculus)
PAK dimer [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
PAK dimer [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
Autophosphorylation of PAK1 (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RAC1 and CDC42 activate PAK1 (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK6/MAPK4 signaling (Mus musculus)
Activation of PAKs by RAC1 and CDC42 (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Autophosphorylation of PAK1,2,3 (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Mus musculus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G-protein beta:gamma signalling (Mus musculus)
G beta:gamma signalling through CDC42 (Mus musculus)
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1 binds ARHGEF6 (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
VEGFR2 mediated vascular permeability (Mus musculus)
PAK1-3 autophosphorylates (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1-3 dimer disassociates (Mus musculus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RAC1 binds PAK1-3 (Mus musculus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases activate PAKs (Mus musculus)
Autophosphorylation of PAK1,2,3 (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Mus musculus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
NF2 binds PAK1 (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1:NF2 [plasma membrane] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RAC1 and CDC42 activate PAK1 (Mus musculus)
PAK1 [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RHO GTPase cycle (Mus musculus)
RAC1 GTPase cycle (Mus musculus)
RAC1 binds effectors at the plasma membrane (Mus musculus)
RAC1 effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RAC1:GTP:RAC1 effectors [plasma membrane] (Mus musculus)
RAC1 effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RAC2 GTPase cycle (Mus musculus)
RAC2 binds effectors at the plasma membrane (Mus musculus)
RAC2 plasma membrane effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Mus musculus)
RAC2 plasma membrane effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RAC3 GTPase cycle (Mus musculus)
RAC3 binds effectors at the plasma membrane (Mus musculus)
RAC3 effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RAC3:GTP:RAC3 effectors [plasma membrane] (Mus musculus)
RAC3 effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RHOH GTPase cycle (Mus musculus)
RHOH binds effectors at the plasma membrane (Mus musculus)
RHOH effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RHOH:GTP:RHOH effectors [plasma membrane] (Mus musculus)
RHOH effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RHOQ GTPase cycle (Mus musculus)
RHOQ binds effectors at the plasma membrane (Mus musculus)
RHOQ effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Mus musculus)
RHOQ effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RHOU GTPase cycle (Mus musculus)
RHOU binds effectors at the plasma membrane (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RHOU:GTP:RHOU effectors [plasma membrane] (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RHOV GTPase cycle (Mus musculus)
RHOV binds effectors at the plasma membrane (Mus musculus)
RHOV effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
RHOV:GTP:RHOV effectors [plasma membrane] (Mus musculus)
RHOV effectors [cytosol] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
PAK1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O88643
Reference Genes
ENSEMBL:ENSMUSG00000030774
Participates
as a member of
PAK1/3, 2 [cytosol] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
as an output of
Interaction of PAK1 with Rac1-GTP (Mus musculus)
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Mus musculus)
RAC1 and CDC42 activate PAK1 (Mus musculus)
as an input of
PAK1 binds ARHGEF6 (Mus musculus)
as a component of
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Mus musculus)
PAK1 dimer [cytosol] (Mus musculus)
Other forms of this molecule
PAK1 [plasma membrane]
phospho-p-S144,T423-PAK1 [plasma membrane]
phospho-p-S144,T423-PAK1 [cytosol]
Inferred From
Active PAK1 [cytosol]
(Homo sapiens)
PAK1 [cytosol]
(Homo sapiens)
Cross References
IntEnz
2.7.11.1
PRO
O88643
MGI
1339975
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60766 Cdc42
3
CDC42 [endoplasmic reticulum membrane]
(R-MMU-5672086)
CDC42 [cytosol]
(R-MMU-442630)
Cdc42 [plasma membrane]
(R-MMU-448841)
0.589
2
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