Phosphorylation of mpChREBP (Thr 666) at Ser(196) by mPKA

Stable Identifier
R-MMU-164055
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of mpChREBP (Thr 666) at Ser(196) by mPKA
Phosphorylation of ChREBP (Carbohydrate Response Element Binding Protein) at serine 196 by PKA inhibits its nuclear translocation. This reaction has been studied in detail using mouse proteins (Kawaguchi et al. 2001); the human version of the reaction is inferred from these studies.
Literature References
PubMed ID Title Journal Year
11698644 Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein

Uyeda, K, Kabashima, T, Kawaguchi, T, Takenoshita, M

Proc Natl Acad Sci U S A 2001
Participants
Input
Output
Catalyst Activity

cAMP-dependent protein kinase activity of Prkaca [cytosol]

Physical Entity
Prkaca [cytosol] (Mus musculus)
Activity
cAMP-dependent protein kinase activity (GO:0004691)
This event is regulated
Negatively by
Regulator
Prkaca [cytosol] (Mus musculus)
Orthologous Events
Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA (Homo sapiens)
Created
Gopinathrao, G  (2005-05-11)
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