Reactome | Active mTORC1 complex [lysosomal membrane]

Active mTORC1 complex [lysosomal membrane]

Stable Identifier

R-MMU-165678

Type

Complex

Species

Mus musculus

Compartment

lysosomal membrane

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
RHEB:GTP [lysosomal membrane] (Mus musculus)

Participates

as an input of

AKT1S1 (PRAS40) binds mTORC1 (Mus musculus)
AMPK phosphorylates Raptor in the mTORC1 complex (Mus musculus)
Rheb in the MTORC1 complex hydrolyses GTP (Mus musculus)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)
Active MTORC1 binds the ULK1 complex (Mus musculus)

as a component of

mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Mus musculus)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Mus musculus)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)

as an output of

Formation of active mTORC1 complex (Mus musculus)

This entity regulates

Negatively

MAF1 translocates to the nucleus (Mus musculus)

Inferred From

Active mTORC1 complex [lysosomal membrane] (Homo sapiens)

MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)

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