Reactome | Myd88 [cytosol]

Myd88 [cytosol]

Stable Identifier

R-MMU-166059

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

MYD88, P22366

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Death Receptor Signaling (Mus musculus)
  - p75 NTR receptor-mediated signalling (Mus musculus)
    - p75NTR signals via NF-kB (Mus musculus)
      - p75NTR recruits signalling complexes (Mus musculus)
        
        IRAK interacts with TRAF6 (Mus musculus)
        
        NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Mus musculus)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Mus musculus)
        
        MYD88 dimer [cytosol] (Mus musculus)
        
        Myd88 [cytosol] (Mus musculus)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Mus musculus)
        
        MYD88 dimer [cytosol] (Mus musculus)
        
        Myd88 [cytosol] (Mus musculus)
        
        MYD88 dissociates (Mus musculus)
        
        MYD88 dimer [cytosol] (Mus musculus)
        
        Myd88 [cytosol] (Mus musculus)
        
        NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Mus musculus)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Mus musculus)
        
        MYD88 dimer [cytosol] (Mus musculus)
        
        Myd88 [cytosol] (Mus musculus)
- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - Negative regulation of the PI3K/AKT network (Mus musculus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
        
        PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Mus musculus)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Mus musculus)
        
        MYD88 dimer [cytosol] (Mus musculus)
        
        Myd88 [cytosol] (Mus musculus)
    - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
      - IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Mus musculus)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Mus musculus)
        
        MYD88 dimer [cytosol] (Mus musculus)
        
        Myd88 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P22366

Gene Names

Myd88

Reference Genes

BioGPS Gene:17874 Myd88

ENSEMBL:ENSMUSG00000032508

KEGG:mmu:17874 Myd88

Monarch:17874 Myd88

NCBI Gene:17874 Myd88

UCSC:P22366 Myd88

Reference Transcript

RefSeq:NM_010851.2 Myd88

Other Identifiers

102430_at

10597648

1419272_at

17532137

17874

4638815

4656276

4800459

4937089

4987033

5035321

5333095

5369030

5384674

5597365

A_52_P282762

GE35773

GO:0002238

GO:0002269

GO:0002283

GO:0002376

GO:0002755

GO:0003824

GO:0005102

GO:0005121

GO:0005149

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006325

GO:0006338

GO:0006355

GO:0006909

GO:0006915

GO:0006954

GO:0006955

GO:0007165

GO:0007166

GO:0007178

GO:0007254

GO:0008063

GO:0009615

GO:0009682

GO:0009986

GO:0010467

GO:0010468

GO:0010628

GO:0012501

GO:0014004

GO:0014070

GO:0014075

GO:0016064

GO:0016192

GO:0019221

GO:0019897

GO:0022008

GO:0030154

GO:0031234

GO:0031663

GO:0032481

GO:0032494

GO:0032496

GO:0032675

GO:0032680

GO:0032722

GO:0032731

GO:0032740

GO:0032747

GO:0032755

GO:0032757

GO:0032760

GO:0032991

GO:0034142

GO:0034146

GO:0034158

GO:0035325

GO:0035591

GO:0038124

GO:0038172

GO:0042127

GO:0042742

GO:0042802

GO:0043123

GO:0043200

GO:0043226

GO:0043588

GO:0045087

GO:0045471

GO:0045944

GO:0046330

GO:0048661

GO:0048856

GO:0050671

GO:0050727

GO:0050830

GO:0051607

GO:0060090

GO:0060337

GO:0060907

GO:0070498

GO:0070555

GO:0070935

GO:0070944

GO:0070976

GO:0071260

GO:0090557

GO:0098542

GO:0140052

GO:0140096

GO:0140097

GO:0140104

GO:0140657

GO:0140674

GO:1900017

GO:1900227

GO:1902622

GO:2000338

GO:2000341

ILMN_2971767

Msa.2476.0_at

Participates

as an input of

DHX36 or DHX9 binds MyD88 (Mus musculus)

as a component of

Inferred From

MYD88 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_034981.1

ENSEMBL

ENSMUST00000035092, ENSMUSP00000035092, ENSMUSG00000032508

PRO

P22366

MGI

108005

HMDB Protein

HMDBP13842

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8R4K2	2	phospho-p-T342,T345,S346-IRAK4 [cytosol] (R-MMU-446649) IRAK4 [cytosol] (R-MMU-166081)	0.748	8
UniProt:Q9QUN7	2	Tlr2 [secretory granule membrane] (R-MMU-6804777) Tlr2 [plasma membrane] (R-MMU-167992)	0.702	4
UniProt:Q62406 Irak1	9	Irak1 [cytosol] (R-MMU-9027461) phospho-p-S376,T387-IRAK1 [cytosol] (R-MMU-446687) phospho-K63polyUb-hp-IRAK1 [endosome membrane] (R-MMU-975112) phospho-p-S,T-IRAK1 [cytosol] (R-MMU-3149574) phospho-K63polyUb-hp-IRAK1 [cytosol] (R-MMU-451565) phospho-p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-MMU-975157) phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-MMU-937011) phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-MMU-446682) IRAK1 [cytosol] (R-MMU-446639)	0.688	3
UniProt:Q60803	3	Traf3 [cytosol] (R-MMU-936556) Traf3 [cytosol] (R-MMU-914241) Traf3 [cytosol] (R-MMU-936402)	0.677	5
UniProt:P70196 Traf6	9	Traf6 [cytosol] (R-MMU-6783233) Traf6 [cytosol] (R-MMU-6782845) Traf6 [cytosol] (R-MMU-933459) Traf6 [endosome membrane] (R-MMU-450272) Traf6 [endosome membrane] (R-MMU-450227) Traf6 [plasma membrane] (R-MMU-936955) Traf6 [plasma membrane] (R-MMU-936980) Traf6 [cytosol] (R-MMU-2685681) Traf6 [cytosol] (R-MMU-166366)	0.623	4
UniProt:P13504	1	Il1r1 [plasma membrane] (R-MMU-197595)	0.589	2
UniProt:Q9WUU8	1	Tnip1 [cytosol] (R-MMU-5690853)	0.576	3
UniProt:Q9QUK6	2	Tlr4 [endosome membrane] (R-MMU-2201285) Tlr4 [plasma membrane] (R-MMU-166045)	0.564	2
UniProt:Q8CFA1	4	phospho-p-IRAK2 [endosome membrane] (R-MMU-975187) IRAK2 [cytosol] (R-MMU-772534) phospho-p-IRAK2 [plasma membrane] (R-MMU-936949) phospho-p-IRAK2 [cytosol] (R-MMU-446636)	0.527	5
UniProt:Q9EQ32	1	phospho-Pik3ap1 [plasma membrane] (R-MMU-984814)	0.524	2
UniProt:P35991 Btk	4	p-Y551,Y223-Btk [cytosol] (R-MMU-9606999) p-Y551-Btk [cytosol] (R-MMU-9607001) Btk [cytosol] (R-MMU-2685636) phospho-p-Y223,Y551-BTK [plasma membrane] (R-MMU-984807)	0.499	2
UniProt:Q3TTA7	1	CBLB [cytosol] (R-MMU-976009)	0.499	2
UniProt:P15314	1	Irf1 [nucleoplasm] (R-MMU-983456)	0.471	2
UniProt:P58753 TIRAP	2	p-4Y-TIRAP [plasma membrane] (R-HSA-2201321) TIRAP [cytosol] (R-HSA-166141)	0.462	3

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