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Traf6 [cytosol]
Stable Identifier
R-MMU-166366
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
TRAF6, P70196
Locations in the PathwayBrowser for interactor UniProt:Q96CG3 TIFA
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
Translocation of TRAF6 to CBM complex (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
IRAK1 induces oligomerisation of TRAF6 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p62:MEKK3 binds to TRAF6 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Alpha-protein kinase 1 signaling pathway (Mus musculus)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Mus musculus)
Traf6 [cytosol] (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
TRAF6 binds MALT1 oligomers (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 oligomerizes (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated NF-kB activation (Mus musculus)
Oligomerization of TRAF6 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
IRAK2 induces TRAF6 oligomerization (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
IRAK2 induces TRAF6 oligomerization (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
IRAK2 induces TRAF6 oligomerization (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Mus musculus)
Activated TLR4:TICAM1 recruits TRAF6 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
IRAK2 induces TRAF6 oligomerization (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
IRAK2 induces TRAF6 oligomerization (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Regulated proteolysis of p75NTR (Mus musculus)
p75NTR ICD signals to NF-kB (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p75NTR signals via NF-kB (Mus musculus)
p75NTR recruits signalling complexes (Mus musculus)
IRAK interacts with TRAF6 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P70196-2 Traf6
Gene Names
Traf6
Participates
as a component of
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Mus musculus)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Mus musculus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
MEKK1:activated TRAF6 [cytosol] (Mus musculus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Mus musculus)
hp-IRAK1:3xTRAF6 [cytosol] (Mus musculus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Mus musculus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
MALT1oligomer:TRAF6 [cytosol] (Mus musculus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Mus musculus)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
TRAF6 homotrimer [cytosol] (Mus musculus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Mus musculus)
as an input of
IRAK2 induces TRAF6 oligomerization (Mus musculus)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Mus musculus)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Mus musculus)
Activated TLR4:TICAM1 recruits TRAF6 (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
Translocation of TRAF6 to CBM complex (Mus musculus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)
IRAK1 induces oligomerisation of TRAF6 (Mus musculus)
p62:MEKK3 binds to TRAF6 (Mus musculus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Mus musculus)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Mus musculus)
Oligomerization of TRAF6 (Mus musculus)
TRAF6 binds MALT1 oligomers (Mus musculus)
TRAF6 oligomerizes (Mus musculus)
p75NTR ICD signals to NF-kB (Mus musculus)
IRAK interacts with TRAF6 (Mus musculus)
as a member of
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Mus musculus)
as a repeated unit of
TRAF6 oligomer [cytosol] (Mus musculus)
Other forms of this molecule
Traf6 [cytosol]
Traf6 [cytosol]
TNF receptor associated factor 6 isoform 2 [cytosol]
Traf6 [endosome membrane]
Traf6 [endosome membrane]
Traf6 [plasma membrane]
Traf6 [plasma membrane]
Traf6 [cytosol]
Inferred From
TRAF6 [cytosol]
(Homo sapiens)
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62991 UBIQ
0.835
5
UniProt:Q9QZH6
2
Ecsit [mitochondrial inner membrane]
(R-MMU-5689047)
Ecsit [cytosol]
(R-MMU-168064)
0.729
5
UniProt:P22366
1
Myd88 [cytosol]
(R-MMU-166059)
0.623
4
UniProt:Q61084
1
MAP3K3 [cytosol]
(R-MMU-507725)
0.589
5
UniProt:Q8C0E5 Q8C0E5
0.581
3
UniProt:Q8N7N6 CIKS
0.547
4
UniProt:Q8K4B2
1
IRAK3 [cytosol]
(R-MMU-166103)
0.547
3
UniProt:Q62227
1
Nr0b2 [nucleoplasm]
(R-MMU-376312)
0.537
5
UniProt:P17879
4
HSPA1A [nucleoplasm]
(R-MMU-6792605)
HSPA1A [extracellular region]
(R-MMU-6805872)
HSPA1A [ficolin-1-rich granule lumen]
(R-MMU-6801496)
HSPA1A [cytosol]
(R-MMU-6792602)
0.524
3
UniProt:Q9EQY0
2
phospho-p-S724-ERN1 [endoplasmic reticulum membrane]
(R-MMU-381029)
ERN1 [endoplasmic reticulum membrane]
(R-MMU-381076)
0.524
6
UniProt:Q793I8
2
Tifa [cytosol]
(R-MMU-451582)
phospho-Tifa [cytosol]
(R-MMU-9645512)
0.508
2
UniProt:P27512
1
Cd40 [plasma membrane]
(R-MMU-198117)
0.508
2
UniProt:O35305
1
TNFRSF11A [plasma membrane]
(R-MMU-5668756)
0.508
2
UniProt:Q96CG3 TIFA
2
TIFA [cytosol]
(R-HSA-451582)
p-T9-TIFA [cytosol]
(R-HSA-9645512)
0.499
4
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