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phospho-p-4Y-PLCG1 [plasma membrane]
Stable Identifier
R-MMU-167679
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
Q62077
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
TCR signaling (Mus musculus)
Generation of second messenger molecules (Mus musculus)
PLC-gamma1 hydrolyses PIP2 (Mus musculus)
p-PLCG [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Translocation of PLC-gamma1 to PIP2 (Mus musculus)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Innate Immune System (Mus musculus)
DAP12 interactions (Mus musculus)
DAP12 signaling (Mus musculus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Mus musculus)
p-4Y-PLCG [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Release of p-PLCG1 (Mus musculus)
p-4Y-PLCG [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Mus musculus)
p-4Y-PLCG [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated Ca+2 mobilization (Mus musculus)
Hydrolysis of PIP2 by PLCG (Mus musculus)
p-4Y-PLCG [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Mus musculus)
p-4Y-PLCG [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Role of phospholipids in phagocytosis (Mus musculus)
Phosphorylation and activation of PLCG (Mus musculus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Mus musculus)
p-PLCG [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Release of PLCG from FCGR (Mus musculus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Mus musculus)
p-PLCG [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
p-PLCG [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
Active ALK phosphorylates PLCG1 (Mus musculus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Signaling by EGFR (Mus musculus)
EGFR interacts with phospholipase C-gamma (Mus musculus)
Active PLC-gamma1 dissociates from EGFR (Mus musculus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
EGFR activates PLC-gamma1 by phosphorylation (Mus musculus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Signaling by FGFR (Mus musculus)
Signaling by FGFR1 (Mus musculus)
Downstream signaling of activated FGFR1 (Mus musculus)
Phospholipase C-mediated cascade: FGFR1 (Mus musculus)
Activated FGFR1 phosphorylates PLCG1 (Mus musculus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
p-4Y-PLCG1 dissociates from activated FGFR1 (Mus musculus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Signaling by FGFR2 (Mus musculus)
Downstream signaling of activated FGFR2 (Mus musculus)
Phospholipase C-mediated cascade; FGFR2 (Mus musculus)
Activated FGFR2 phosphorylates PLCG1 (Mus musculus)
activated FGFR2:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
p-4Y-PLCG1 dissociates from activated FGFR2 (Mus musculus)
activated FGFR2:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Signaling by FGFR3 (Mus musculus)
Downstream signaling of activated FGFR3 (Mus musculus)
Phospholipase C-mediated cascade; FGFR3 (Mus musculus)
Activated FGFR3 phosphorylates PLCG1 (Mus musculus)
activated FGFR3:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
p-4Y-PLCG1 dissociates from activated FGFR3 (Mus musculus)
activated FGFR3:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Signaling by FGFR4 (Mus musculus)
Downstream signaling of activated FGFR4 (Mus musculus)
Phospholipase C-mediated cascade; FGFR4 (Mus musculus)
Activated FGFR4 phosphorylates PLCG1 (Mus musculus)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
p-4Y-PLCG1 dissociates from activated FGFR4 (Mus musculus)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK2 (TRKB) (Mus musculus)
Activated NTRK2 signals through PLCG1 (Mus musculus)
Activated PCLG1 dissociates from NTRK2 (Mus musculus)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Signaling by NTRK3 (TRKC) (Mus musculus)
Activated NTRK3 signals through PLCG1 (Mus musculus)
Activated PCLG1 dissociates from NTRK3 (Mus musculus)
NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Signaling by PDGF (Mus musculus)
Downstream signal transduction (Mus musculus)
Activated PLC gamma dissociates from the PDGF receptor (Mus musculus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Phosphorylation of PLCgamma by PDGFR (Mus musculus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
VEGFR2 mediated cell proliferation (Mus musculus)
PLCG1 disassociates from VEGFR2 and translocate to PM (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
SFKs phosphorylate PLCG1 (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-4Y-PLCG1 [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:Q62077 Plcg1
Gene Names
Plcg1, Plcg-1
Chain
initiator methionine:, chain:2-1302
Reference Genes
BioGPS Gene:18803 Plcg1
KEGG:mmu:18803 Plcg1
Monarch:18803 Plcg1
NCBI Gene:18803 Plcg1
UCSC:Q62077 Plcg1
Reference Transcript
RefSeq:NM_021280.3 Plcg1
Other Identifiers
10478219
107396_at
1435149_at
17379037
18803
4313171
4365734
4455921
4513930
4534490
4534847
4631655
4643267
4654394
4657911
4660184
4685719
4704609
4706597
4734610
4827232
4854114
4896963
4911984
4918218
4922824
4998849
5022085
5034970
5072212
5072615
5103859
5123745
5155491
5208646
5210433
5222069
5240233
5242247
5267072
5269972
5292670
5340553
5398774
5449655
5458424
5465111
5481891
5491235
5544187
5546808
5570745
5587302
5588535
A_52_P148678
A_52_P672850
A_55_P2015860
A_55_P2182795
A_66_P120232
GE1571604
GO:0001701
GO:0001726
GO:0002376
GO:0003824
GO:0004435
GO:0004629
GO:0005085
GO:0005158
GO:0005168
GO:0005509
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006629
GO:0006816
GO:0007165
GO:0007173
GO:0008081
GO:0008180
GO:0009395
GO:0010634
GO:0016042
GO:0016477
GO:0016787
GO:0019722
GO:0019901
GO:0030027
GO:0030136
GO:0030971
GO:0031161
GO:0031410
GO:0032587
GO:0032957
GO:0032959
GO:0035254
GO:0035556
GO:0042995
GO:0043226
GO:0043536
GO:0045766
GO:0046488
GO:0046872
GO:0048015
GO:0048856
GO:0048870
GO:0050429
GO:0050804
GO:0050852
GO:0051209
GO:0051219
GO:0051281
GO:0055085
GO:0071364
GO:0098685
GO:0098772
GO:0098978
GO:1904643
GO:1905564
GO:2000353
ILMN_1227561
Msa.15085.0_s_at
mMC007422
Participates
as a component of
Active ALK:p-4Y PLCG1 [plasma membrane] (Mus musculus)
NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Mus musculus)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
activated FGFR2:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
activated FGFR3:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Mus musculus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Mus musculus)
as a member of
p-4Y-PLCG [plasma membrane] (Mus musculus)
p-PLCG [plasma membrane] (Mus musculus)
as an output of
Activated PCLG1 dissociates from NTRK3 (Mus musculus)
Activated PCLG1 dissociates from NTRK2 (Mus musculus)
p-4Y-PLCG1 dissociates from activated FGFR4 (Mus musculus)
p-4Y-PLCG1 dissociates from activated FGFR2 (Mus musculus)
PLCG1 disassociates from VEGFR2 and translocate to PM (Mus musculus)
p-4Y-PLCG1 dissociates from activated FGFR1 (Mus musculus)
p-4Y-PLCG1 dissociates from activated FGFR3 (Mus musculus)
Activated PLC gamma dissociates from the PDGF receptor (Mus musculus)
Active PLC-gamma1 dissociates from EGFR (Mus musculus)
Other forms of this molecule
p-Y-Plcg1 [cytosol]
Plcg1 [cytosol]
p-4Y-Plcg1 [plasma membrane]
phospho-p-Y771,Y783-PLCG1 [plasma membrane]
phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol]
PLCG1 [plasma membrane]
P-Plcg1 [cytosol]
Plcg1 [plasma membrane]
PLCG1 [cytosol]
Inferred From
p-4Y-PLCG1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 472
Coordinate
472
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 771
Coordinate
771
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 783
Coordinate
783
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1253
Coordinate
1253
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_067255.2
ENSEMBL
ENSMUST00000103115
,
ENSMUSP00000099404
IntEnz
3.1.4.11
PRO
Q62077
GlyGen
Q62077
MGI
97615
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O54957
4
phospho-Lat [plasma membrane]
(R-MMU-434829)
Lat [plasma membrane]
(R-MMU-202322)
phospho-Lat [plasma membrane]
(R-MMU-202364)
phospho-Lat [plasma membrane]
(R-MMU-2396597)
0.669
5
UniProt:P14753 Epor
4
p-8Y-Epor [plasma membrane]
(R-MMU-9006275)
EpoR [plasma membrane]
(R-MMU-206154)
Epor [plasma membrane]
(R-MMU-1168347)
phospho-Epor [plasma membrane]
(R-MMU-9006274)
0.591
4
UniProt:Q60631 Grb2
1
Grb2 [cytosol]
(R-MMU-443287)
0.564
2
UniProt:P48356 Lepr
0.508
2
UniProt:Q3U1F9
2
Pag1 [plasma membrane]
(R-MMU-180500)
phospho-Pag1 [plasma membrane]
(R-MMU-180494)
0.499
2
UniProt:P07949 RET
2
RET [plasma membrane]
(R-HSA-8853797)
p-5Y-RET [plasma membrane]
(R-HSA-8854162)
0.482
2
UniProt:P35438 Grin1
3
Grin1 [plasma membrane]
(R-MMU-3928395)
Grin1 [endoplasmic reticulum membrane]
(R-MMU-9610359)
Grin1 [transport vesicle membrane]
(R-MMU-9610566)
0.462
2
UniProt:P35918 Kdr
5
p-Y799,Y1052,Y1172-Kdr [plasma membrane]
(R-MMU-9860469)
Kdr [plasma membrane]
(R-MMU-9860502)
Mouse Vegfr2-Human CSF1R fusion protein [plasma membrane]
(R-MMU-5218738)
VEGFR2 [plasma membrane]
(R-MMU-195382)
phospho-p-6Y-VEGFR2 [plasma membrane]
(R-MMU-4420103)
0.462
2
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