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CHUK:IKBKB:IKBKG [cytosol]
Stable Identifier
R-MMU-168113
Type
Complex
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to mechanical stimuli (Mus musculus)
Response of endothelial cells to shear stress (Mus musculus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Mus musculus)
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
Activation of IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Antiviral mechanism by IFN-stimulated genes (Mus musculus)
PKR-mediated signaling (Mus musculus)
IKK complex is activated by PKR (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Modulation of host responses by IFN-stimulated genes (Mus musculus)
FKBP5 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
NEMO binds polyubiquitinated IRAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated NF-kB activation (Mus musculus)
Phosphorylation of IKK-beta by TAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
IKK complex recruitment mediated by RIP1 (Mus musculus)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
GNB2L1 binds IKKA:IKKB:NEMO (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKKA:IKKB:NEMO:GNB2L1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TNFR1-induced NF-kappa-B signaling pathway (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
CHUK [cytosol]
(Mus musculus)
IKBKB [cytosol]
(Mus musculus)
IKBKG [cytosol]
(Mus musculus)
Participates
as an input of
FKBP5 binds CHUK:IKBKB:IKBKG (Mus musculus)
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Mus musculus)
IKK complex is activated by PKR (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)
GNB2L1 binds IKKA:IKKB:NEMO (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Mus musculus)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Mus musculus)
Activation of IKK complex (Mus musculus)
Phosphorylation of IKK-beta by TAK1 (Mus musculus)
NEMO binds polyubiquitinated IRAK1 (Mus musculus)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
as a component of
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Mus musculus)
IKKA:IKKB:NEMO:GNB2L1 [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Mus musculus)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
as an output of
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
Inferred From
CHUK:IKBKB:IKBKG [cytosol]
(Homo sapiens)
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