Reactome | SYT1 [plasma membrane]

SYT1 [plasma membrane]

Stable Identifier

R-MMU-168786

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

P46096

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - STON2 binds SYT proteins (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        SYT1 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P46096

Reference Genes

BioGPS Gene:20979

ENSEMBL:ENSMUSG00000035864

KEGG:mmu:20979

Monarch:20979

NCBI Gene:20979

UCSC:P46096

Reference Transcript

Other Identifiers

10372324

105700_at

113587_at

1421990_at

1431191_a_at

1433884_at

1438282_at

17244843

20979

4360464

4367479

4371588

4390377

4400297

4468268

4483145

4533954

4587873

4616588

4621709

4652785

4694016

4711934

4899617

4962303

5003568

5031224

5064802

5120789

5189577

5265981

5331361

5343265

5349702

5480387

5532218

5532634

5545681

5584700

5603994

93005_at

A_51_P297900

A_51_P298873

A_52_P103929

A_52_P41090

A_52_P679799

A_52_P94201

A_55_P2058957

A_55_P2718027

A_55_P2718032

D37792_s_at

GE33752

GO:0000149

GO:0001786

GO:0005509

GO:0005513

GO:0005515

GO:0005516

GO:0005543

GO:0005544

GO:0005546

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006906

GO:0007269

GO:0008021

GO:0008289

GO:0014059

GO:0014069

GO:0016020

GO:0016050

GO:0016079

GO:0016192

GO:0017075

GO:0017158

GO:0019905

GO:0030141

GO:0030154

GO:0030276

GO:0030348

GO:0030424

GO:0030672

GO:0031045

GO:0031338

GO:0031340

GO:0031410

GO:0033603

GO:0042584

GO:0042734

GO:0042802

GO:0043005

GO:0043226

GO:0044306

GO:0045202

GO:0045211

GO:0045956

GO:0046872

GO:0046982

GO:0048278

GO:0048306

GO:0048488

GO:0048786

GO:0048791

GO:0050750

GO:0050806

GO:0051291

GO:0051592

GO:0051966

GO:0060076

GO:0060090

GO:0061024

GO:0061669

GO:0061891

GO:0065003

GO:0070382

GO:0071277

GO:0071911

GO:0098686

GO:0098746

GO:0098978

GO:0099502

GO:0099523

GO:0099524

GO:0140299

GO:0140693

GO:0140694

GO:1903235

GO:1903305

GO:1903861

GO:2000300

ILMN_1224963

ILMN_1226085

ILMN_2608410

ILMN_2608416

mMC018419

mMR026348

Participates

as a component of

SYT1 dimer [plasma membrane] (Mus musculus)

as an output of

Other forms of this molecule

SYT1 [clathrin-coated endocytic vesicle membrane]

SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]

SYT1 [clathrin-sculpted glutamate transport vesicle membrane]

SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

SYT1 [clathrin-sculpted monoamine transport vesicle membrane]

Inferred From

SYT1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001239271.1, XP_017169355.1, XP_006513510.1, XP_006513511.1, NP_033332.1, NP_001239270.1, XP_006513509.1

ENSEMBL

ENSMUST00000064054, ENSMUST00000105276, ENSMUSP00000063293, ENSMUSP00000100912, ENSMUSG00000035864

PRO

P46096

GlyGen

P46096

MGI

99667

PDB

5T0S, 5VFG, 5T0R, 5VFF, 5VFE

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49769 Psen1	7	Psen1 N-term fragment [plasma membrane] (R-MMU-2534198) Psen1 [plasma membrane] (R-MMU-201606) Psen1 [azurophil granule membrane] (R-MMU-6799234) Psen1 [azurophil granule membrane] (R-MMU-6799235) Psen1 [azurophil granule membrane] (R-MMU-6799209) Psen1(1-298) [plasma membrane] (R-MMU-206283) Psen1(299-467) [plasma membrane] (R-MMU-2534227)	0.571	6
UniProt:Q62108 Dlg4	3	SAP-90 [plasma membrane] (R-MMU-443606) Dlg4 [endocytic vesicle membrane] (R-MMU-416847) Dlg4 [cytosol] (R-MMU-6794267)	0.527	3
UniProt:Q8TAC9 SCAM5			0.524	2

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