Reactome | Psmd8 [nucleoplasm]

Psmd8 [nucleoplasm]

Stable Identifier

R-MMU-174318

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

PSMD8, Q9CX56

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G1/S DNA Damage Checkpoints (Mus musculus)
    - p53-Independent G1/S DNA Damage Checkpoint (Mus musculus)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Mus musculus)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        Psmd8 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Cyclin E associated events during G1/S transition (Mus musculus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        Psmd8 [nucleoplasm] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        Psmd8 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        Psmd8 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        Psmd8 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to chemical stress (Mus musculus)
    - KEAP1-NFE2L2 pathway (Mus musculus)
      - Nuclear events mediated by NFE2L2 (Mus musculus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Mus musculus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        Psmd8 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX2 (Mus musculus)
      - Regulation of RUNX2 expression and activity (Mus musculus)
        
        26S proteasome degrades PolyUb-RUNX2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        Psmd8 [nucleoplasm] (Mus musculus)
    - Transcriptional regulation by RUNX3 (Mus musculus)
      - Regulation of RUNX3 expression and activity (Mus musculus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        Psmd8 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CX56 Psmd8

Gene Names

Psmd8

Chain

chain:1-353

Reference Genes

BioGPS Gene:57296 Psmd8

KEGG:mmu:57296 Psmd8

Monarch:57296 Psmd8

NCBI Gene:57296 Psmd8

UCSC:Q9CX56 Psmd8

Reference Transcript

RefSeq:NM_026545.3 Psmd8

Other Identifiers

10561679

1423296_at

17488743

4406748

4407017

4436393

4467959

4498566

4527170

4534658

4563073

4623127

4838211

5083877

5238523

5269239

5375438

5408852

5431357

5443458

5467671

5515921

5540208

57296

98522_at

GE41296

GO:0000502

GO:0003674

GO:0005634

GO:0005838

GO:0006508

GO:0008541

GO:0022624

GO:0030163

GO:0043161

ILMN_2678019

Msa.3963.0_s_at

c76407_rc_at

mMR030778

Participates

as a component of

19S RP lid [nucleoplasm] (Mus musculus)

Other forms of this molecule

Psmd8 [cytosol]

Inferred From

PSMD8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_080821.3

ENSEMBL

ENSMUSP00000139514, ENSMUSG00000030591, ENSMUST00000059642, ENSMUSP00000051657, ENSMUST00000186182

PRO

Q9CX56

MGI

1888669

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