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NEK2 [cytosol]
Stable Identifier
R-MMU-177329
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
O35942
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
M Phase (Mus musculus)
Mitotic Prometaphase (Mus musculus)
Recruitment of NuMA to mitotic centrosomes (Mus musculus)
Association of NuMA with microtubules (Mus musculus)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Mus musculus)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Mus musculus)
Mature centrosome:nucleated microtubules [cytosol] (Mus musculus)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Translocation of NuMA to the centrosomes (Mus musculus)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Mus musculus)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Mitotic G2-G2/M phases (Mus musculus)
G2/M Transition (Mus musculus)
AURKA Activation by TPX2 (Mus musculus)
TPX2 binds AURKA at centrosomes (Mus musculus)
Centrosome:AURKA [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Mus musculus)
Centrosome:AURKA [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
TPX2 promotes AURKA autophosphorylation (Mus musculus)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Mus musculus)
Centrosome:AURKA [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Centrosome:p-T288-AURKA:TPX2:HMMR [cytosol] (Mus musculus)
Centrosome:p-T288-AURKA [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Centrosome maturation (Mus musculus)
Loss of proteins required for interphase microtubule organization from the centrosome (Mus musculus)
Loss of C-Nap-1 from centrosomes (Mus musculus)
cNAP-1 depleted centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Loss of Nlp from mitotic centrosomes (Mus musculus)
Dissociation of Phospho-Nlp from the centrosome (Mus musculus)
Nlp-depleted centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
centrosome containing phosphorylated Nlp [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Plk1-mediated phosphorylation of Nlp (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
centrosome containing phosphorylated Nlp [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Recruitment of mitotic centrosome proteins and complexes (Mus musculus)
Recruitment of CDK11p58 to the centrosomes (Mus musculus)
Centrosomes containing recruited CDK11p58 [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Recruitment of Plk1 to centrosomes (Mus musculus)
Centrosome associated Plk1 [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Mus musculus)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Regulation of PLK1 Activity at G2/M Transition (Mus musculus)
AJUBA binds centrosome-associated AURKA (Mus musculus)
Centrosome:AURKA [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Centrosome:AURKA:AJUBA [cytosol] (Mus musculus)
Centrosome:AURKA [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
AJUBA facilitates AURKA autophosphorylation (Mus musculus)
Centrosome:AURKA:AJUBA [cytosol] (Mus musculus)
Centrosome:AURKA [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Centrosome:p-T288-AURKA [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
AURKA phosphorylates PLK1 (Mus musculus)
Centrosome:p-T288-AURKA [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Mus musculus)
Centrosome:p-T288-AURKA [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
BORA binds PLK1 and AURKA (Mus musculus)
Centrosome:p-T288-AURKA [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Mus musculus)
Centrosome:p-T288-AURKA [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Regulation of mitotic cell cycle (Mus musculus)
APC/C-mediated degradation of cell cycle proteins (Mus musculus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Mus musculus)
APC-Cdc20 mediated degradation of Nek2A (Mus musculus)
Association of Nek2A with MCC:APC/C (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Degradation of multiubiquitinated Nek2A (Mus musculus)
Multiubiquitinated Nek2A [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Multiubiquitination of Nek2A (Mus musculus)
Multiubiquitinated Nek2A [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Organelle biogenesis and maintenance (Mus musculus)
Cilium Assembly (Mus musculus)
Anchoring of the basal body to the plasma membrane (Mus musculus)
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Mus musculus)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
mother centriole:C2CD3 [cytosol] (Mus musculus)
mother centriole [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
mother centriole:C2CD3 [cytosol] (Mus musculus)
mother centriole [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
C2CD3 binds the mother centriole (Mus musculus)
mother centriole [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
mother centriole:C2CD3 [cytosol] (Mus musculus)
mother centriole [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Mus musculus)
basal body:transition zone proteins [cytosol] (Mus musculus)
basal body [cytosol] (Mus musculus)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Mus musculus)
basal body:transition zone proteins [cytosol] (Mus musculus)
basal body [cytosol] (Mus musculus)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
CP110 and CEP97 dissociate from the centriole (Mus musculus)
basal body [cytosol] (Mus musculus)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Mus musculus)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
mother centriole:C2CD3 [cytosol] (Mus musculus)
mother centriole [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
MARK4 binds ODF2 in the centriole (Mus musculus)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
mother centriole:C2CD3 [cytosol] (Mus musculus)
mother centriole [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Mus musculus)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
mother centriole:C2CD3 [cytosol] (Mus musculus)
mother centriole [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Mus musculus)
basal body:transition zone proteins [cytosol] (Mus musculus)
basal body [cytosol] (Mus musculus)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Recruitment of transition zone proteins (Mus musculus)
basal body [cytosol] (Mus musculus)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
basal body:transition zone proteins [cytosol] (Mus musculus)
basal body [cytosol] (Mus musculus)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
The distal appendage proteins recruit TTBK2 (Mus musculus)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
mother centriole:C2CD3 [cytosol] (Mus musculus)
mother centriole [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
mother centriole:C2CD3 [cytosol] (Mus musculus)
mother centriole [cytosol] (Mus musculus)
NEK2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O35942
Reference Genes
BioGPS Gene:18005
ENSEMBL:ENSMUSG00000026622
KEGG:mmu:18005
Monarch:18005
NCBI Gene:18005
UCSC:O35942
Reference Transcript
RefSeq:NM_010892.3
Other Identifiers
100885_at
10352767
1417299_at
1437580_s_at
17220844
18005
4305311
4352021
4416120
4419148
4504132
5002962
5078144
5099369
5121429
5139872
5163871
5222455
5291874
5322020
5585790
A_51_P501018
GE35791
GO:0000070
GO:0000228
GO:0000775
GO:0000776
GO:0000794
GO:0000922
GO:0001824
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0005874
GO:0006468
GO:0007010
GO:0007059
GO:0016740
GO:0019903
GO:0022414
GO:0030496
GO:0032206
GO:0032991
GO:0043226
GO:0046602
GO:0046777
GO:0046872
GO:0048856
GO:0051299
GO:0051301
GO:0051321
GO:0051988
GO:0090307
GO:0106310
GO:0140096
GO:1903126
ILMN_1243210
ILMN_2519385
mMC013838
u95610_s_at
Participates
as a component of
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
mother centriole [cytosol] (Mus musculus)
Nlp-depleted centrosome [cytosol] (Mus musculus)
centrosome containing phosphorylated Nlp [cytosol] (Mus musculus)
cNAP-1 depleted centrosome [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
centrosome [cytosol] (Mus musculus)
as an input of
Association of Nek2A with MCC:APC/C (Mus musculus)
Inferred From
NEK2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_035022.2
ENSEMBL
ENSMUST00000027931
,
ENSMUSP00000027931
IntEnz
2.7.11.1
PRO
O35942
MGI
109359
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