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phospho-Shc1 [cytosol]
Stable Identifier
R-MMU-180276
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-Y349,Y350-SHC1, P98083
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by EGFR (Mus musculus)
SHC1 events in EGFR signaling (Mus musculus)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
SHC1 phosphorylation by phosphorylated EGFR (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
Signaling by ERBB2 (Mus musculus)
SHC1 events in ERBB2 signaling (Mus musculus)
SHC1 phosphorylation by ERBB2 heterodimers (Mus musculus)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
Signaling by ERBB4 (Mus musculus)
SHC1 events in ERBB4 signaling (Mus musculus)
Phosphorylation of SHC1 by ERBB4 homodimers (Mus musculus)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Mus musculus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Mus musculus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P98083-2 Shc1
Gene Names
Shc1, Shc, ShcA
Participates
as a component of
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Mus musculus)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
Other forms of this molecule
phospho-Shc1 [cytosol]
Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [plasma membrane]
phospho-Shc1 [plasma membrane]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Shc1 [cytosol]
Shc1 [cytosol]
p-Y239,Y240,Y313-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Shc1 [plasma membrane]
Shc1 [plasma membrane]
Shc1 [plasma membrane]
Shc1-2 [cytosol]
p-Y-Shc1-2 [cytosol]
Inferred From
p-Y349,Y350-SHC1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 349 (in Homo sapiens)
Coordinate
349
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 350 (in Homo sapiens)
Coordinate
350
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001106802.1
,
NP_035498.2
ENSEMBL
ENSMUST00000191485
,
ENSMUSP00000140336
,
ENSMUSP00000035361
,
ENSMUSG00000042626
,
ENSMUST00000039110
,
ENSMUST00000094378
,
ENSMUSP00000091940
,
ENSMUST00000107417
,
ENSMUSP00000103040
PRO
P98083
MGI
98296
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60631 Grb2
3
Grb2 [cytosol]
(R-MMU-74686)
Grb2 [plasma membrane]
(R-MMU-202993)
Grb2 [cytosol]
(R-MMU-443287)
0.899
8
UniProt:Q9JKF1
3
Iqgap1 [plasma membrane]
(R-MMU-381681)
Iqgap1 [secretory granule membrane]
(R-MMU-6804803)
Iqgap1 [cytosol]
(R-MMU-5626371)
0.65
5
UniProt:P35831
1
Ptpn12 [cytosol]
(R-MMU-432933)
0.558
2
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