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Cul5 [cytosol]
Stable Identifier
R-MMU-180528
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
CUL5, Q9D5V5
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
Polyubiquitination of substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
Release of E3 from polyubiquitinated substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by CSF3 (G-CSF) (Mus musculus)
Inactivation of CSF3 (G-CSF) signaling (Mus musculus)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Mus musculus)
Cul5 [cytosol] (Mus musculus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Neddylation (Mus musculus)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul5 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ERBB2 (Mus musculus)
Downregulation of ERBB2 signaling (Mus musculus)
CUL5 mediates ubiquitination of ERBB2 (Mus musculus)
Cul5 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9D5V5 Cul5
Gene Names
Cul5
Chain
chain:1-780
Reference Genes
BioGPS Gene:75717 Cul5
KEGG Gene (Mus musculus):75717 Cul5
Monarch:75717 Cul5
NCBI Gene:75717 Cul5
UCSC:Q9D5V5 Cul5
Reference Transcript
RefSeq:NM_001161618.1 Cul5
RefSeq:NM_027807.3 Cul5
Participates
as an output of
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Mus musculus)
as a component of
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Mus musculus)
CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
Cul5-SCF complex [cytosol] (Mus musculus)
Other forms of this molecule
Cul5 [cytosol]
Cul5 [cytosol]
Inferred From
CUL5 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001155090.1
,
NP_082083.2
PRO
Q9D5V5
MGI
1922967
PDB
2WZK
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