Phosphorylation of Cyclin D1 on Thr-286 by GSK-3 beta

Stable Identifier
R-MMU-182564
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of Cyclin D1 on Thr-286 by GSK-3 beta
Phosphorylation of cyclin D1 on Thr-286 by glycogen synthase kinase-3beta (GSK-3beta) positively regulates proteasomal degradation of D1 (Diehl et al., 1998).
Literature References
PubMed ID Title Journal Year
9832503 Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

Roussel, MF, Sherr, CJ, Diehl, JA, Cheng, M

Genes Dev 1998
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Gsk3b [nucleoplasm]

Physical Entity
Gsk3b [nucleoplasm] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta (Homo sapiens)
Authored
Walworth, N  (2003-06-05)
O'Donnell, M  (2003-06-05)
Reviewed
Manfredi, JJ  (2018-07-10)
Created
Matthews, L  (2006-07-10)
Cite Us!