Reactome | SRC-2 [cytosol]

SRC-2 [cytosol]

Stable Identifier

R-MMU-191648

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

P05480

Locations in the PathwayBrowser

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Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - EPH-Ephrin signaling (Mus musculus)
      - EPH-ephrin mediated repulsion of cells (Mus musculus)
        
        EPHA binds TIAM1 (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        SFKs phosphorylate VAV2,3 (Mus musculus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        p-EPHs bind VAV2,3 (Mus musculus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - EPHA-mediated growth cone collapse (Mus musculus)
        
        NGEF exchanges GTP for GDP on RHOA (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - EPHB-mediated forward signaling (Mus musculus)
        
        EPHB phosphorylates TIAM1 (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        EPHB:NMDAR binds TIAM1 (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
        
        SRC,FYN,YES,LYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - Ephrin signaling (Mus musculus)
        
        EFNB:GRB4 binds GIT1 (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        EFNBs bind SFKs (Mus musculus)
        
        EPHBs:EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        GIT1 binds bPIX (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        PAK binds RAC and bPIX (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        PAKs autophosphorylate (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        bPIX exchanges GTP for GDP on RAC, activating it (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        p-EFNB binds GRB4 (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        SRC,FYN [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - L1CAM interactions (Mus musculus)
      - Recycling pathway of L1 (Mus musculus)
        
        Phosphorylation of L1 by SRC (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - RET signaling (Mus musculus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SRC-1,RAP1GAP [plasma membrane] (Mus musculus)
        
        SRC-1, RAP1GAP [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        SRC-1, RAP1GAP [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Integrin signaling (Mus musculus)
  - Autophosphorylation of SRC (Mus musculus)
    - SRC-2 [cytosol] (Mus musculus)
  - p130Cas linkage to MAPK signaling for integrins (Mus musculus)
    - Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
      - FAK-SRC complex [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by SCF-KIT (Mus musculus)
    - Dimerization of STATs (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - Disassociation and translocation of STATs to the nucleus (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Mus musculus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - Indirect recruitment of GAB2 to p-KIT (Mus musculus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - JAK2 binds to p-KIT (Mus musculus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - Phosphorylation and activation of VAV1 (Mus musculus)
      - SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - Phosphorylation of GAB2 by SFKs (Mus musculus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - Phosphorylation of JAK2 (Mus musculus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - Phosphorylation of SHP2 by SFKs (Mus musculus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - Phosphorylation of STATs (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Mus musculus)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - Recruitment of STATs (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - Regulation of KIT signaling (Mus musculus)
      - Interaction of APS and p-KIT (Mus musculus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - Phosphorylation of APS (Mus musculus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - Recruitment of CBL to KIT (Mus musculus)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - SHP2 interacts with p-KIT (Mus musculus)
      - SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
    - Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
  - Signaling by VEGF (Mus musculus)
    - VEGFA-VEGFR2 Pathway (Mus musculus)
      - Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - CRK binds BCAR1 and or PXN (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - DOCK180:ELMO binds CRK (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - HSP90AA1 binds p-6Y-VEGFR2 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - PXN binds p-6Y,S732-PTK2 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - Phosphorylation of SRC-1 (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - SRC-1 binds p-Y397-PTK2 (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - SRC-1 phosphorylates PTK2-beta (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - SRC-1 phosphorylates SHB (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - SRC-1 phosphorylates p-Y397-PTK2 (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - Src kinases phosphorylate VAV (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - VEGFR2 mediated cell proliferation (Mus musculus)
        
        SFKs phosphorylate PLCG1 (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
      - p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases Activate Formins (Mus musculus)
        
        RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Mus musculus)
        
        RHOD:GTP:DIAPH2:SRC-1 [endosome membrane] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)
        
        SRC-2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P05480 Src

Gene Names

Src

Chain

initiator methionine:, chain:2-535

Reference Genes

BioGPS Gene:20779 Src

KEGG:mmu:20779 Src

Monarch:20779 Src

NCBI Gene:20779 Src

UCSC:P05480 Src

Reference Transcript

Other Identifiers

10477970

108711_at

1423240_at

1450918_s_at

17378721

20779

4447733

4505917

4804560

4812643

4829346

4885575

5034979

5043570

5059963

5091749

5135638

5152044

5256466

5258840

5282146

5302244

5305028

5374549

5400005

5430370

5495801

99388_at

A_51_P426214

A_52_P600547

GE33726

GO:0000122

GO:0001545

GO:0001819

GO:0002102

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005080

GO:0005102

GO:0005158

GO:0005178

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005743

GO:0005764

GO:0005768

GO:0005770

GO:0005773

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005901

GO:0005925

GO:0006355

GO:0006468

GO:0007010

GO:0007155

GO:0007173

GO:0007179

GO:0007229

GO:0007283

GO:0007611

GO:0008284

GO:0009410

GO:0009612

GO:0010447

GO:0010628

GO:0010629

GO:0010632

GO:0010634

GO:0010907

GO:0010954

GO:0014856

GO:0014911

GO:0016004

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0019899

GO:0019901

GO:0019904

GO:0020037

GO:0022407

GO:0022414

GO:0030054

GO:0030154

GO:0030331

GO:0030900

GO:0031333

GO:0031410

GO:0031648

GO:0031667

GO:0032205

GO:0032587

GO:0032869

GO:0033146

GO:0034139

GO:0034330

GO:0034332

GO:0034446

GO:0034614

GO:0035306

GO:0035331

GO:0035556

GO:0036035

GO:0036120

GO:0038166

GO:0042169

GO:0042476

GO:0042542

GO:0043025

GO:0043065

GO:0043066

GO:0043149

GO:0043226

GO:0043274

GO:0044294

GO:0044325

GO:0044877

GO:0045056

GO:0045087

GO:0045453

GO:0045747

GO:0045780

GO:0045785

GO:0045821

GO:0046579

GO:0046628

GO:0046875

GO:0048008

GO:0048011

GO:0048041

GO:0048471

GO:0048477

GO:0048856

GO:0048870

GO:0050731

GO:0050839

GO:0050847

GO:0050877

GO:0051057

GO:0051219

GO:0051222

GO:0051385

GO:0051450

GO:0051602

GO:0051895

GO:0051897

GO:0051902

GO:0060065

GO:0060444

GO:0060491

GO:0060576

GO:0070102

GO:0070161

GO:0070301

GO:0070374

GO:0070542

GO:0070555

GO:0070700

GO:0071222

GO:0071253

GO:0071375

GO:0071393

GO:0071398

GO:0071456

GO:0071498

GO:0071560

GO:0071803

GO:0071897

GO:0086091

GO:0090263

GO:0097060

GO:0097110

GO:0098542

GO:0098609

GO:0098772

GO:0098978

GO:0099091

GO:0140096

GO:1900182

GO:1902533

GO:1902737

GO:1904263

GO:1904385

GO:1904707

GO:1990646

GO:2000256

GO:2000386

GO:2000394

GO:2000588

GO:2000641

GO:2000811

GO:2001237

GO:2001243

GO:2001286

ILMN_1254757

ILMN_2638454

ILMN_2638455

ILMN_2677529

ILMN_3148543

Msa.1184.0_at

mMC016824

mMR030435

Participates

as a component of

as an input of

as a member of

Other forms of this molecule

phospho-MyrG-p-Y419-SRC [plasma membrane]

SRC-1 [plasma membrane]

phospho-MyrG,p-Y530-SRC [plasma membrane]

phospho-p-Y419-SRC [cytosol]

Src [cytosol]

phospho-p-Y419-SRC-1 [plasma membrane]

MyrG-SRC [plasma membrane]

phospho-p-Y419-SRC [cytosol]

SRC [cytosol]

MyrG-p-Y424-Src [plasma membrane]

Activated Src [nucleoplasm]

p-Y416-Src [cytosol]

Inferred From

Activated SRC-1 [cytosol] (Homo sapiens)

SRC-2 [cytosol] (Homo sapiens)

SRC-1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001020566.1, NP_033297.2

ENSEMBL

ENSMUSP00000090237, ENSMUST00000109533, ENSMUST00000029175, ENSMUST00000092576, ENSMUSP00000105155, ENSMUSP00000105157, ENSMUST00000109529, ENSMUSP00000029175, ENSMUST00000109531, ENSMUSP00000105159

ZINC - Substances

SRC_MOUSE

ZINC target

P05480

PRO

P05480

MGI

98397

ZINC - Predictions - Purchasable

SRC_MOUSE

GlyGen

P05480

PDB

6F3F, 8XN8

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.683	5
UniProt:P31016 Dlg4	3	Dlg4 [plasma membrane] (R-RNO-9612601) Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [cytosol] (R-RNO-6794248)	0.645	9
UniProt:P19367 HK1	4	HK1 [cytosol] (R-HSA-70395) HK1 L529S [cytosol] (R-HSA-5621861) HK1 H577_C672del [cytosol] (R-HSA-5621873) HK1 T680S [cytosol] (R-HSA-5621880)	0.644	8
UniProt:Q13507-3 TRPC3			0.602	4
UniProt:P52789 HK2	1	HK2 [cytosol] (R-HSA-70378)	0.602	4
UniProt:P34152 Ptk2	13	phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-MMU-8874613) phospho-p-Y194,Y397-PTK2 [cytosol] (R-MMU-8874600) phospho-pY-PTK2 [cytosol] (R-MMU-9632393) p-Y428-FAK1 [cytosol] (R-MMU-3928397) Fak1 [cytosol] (R-MMU-3928448) phospho-p-6Y,S732-PTK2 [cytosol] (R-MMU-5218694) phospho-p-5Y,S732-PTK2 [cytosol] (R-MMU-5229006) phospho-p-5Y-PTK2 [cytosol] (R-MMU-5218711) PTK2(773-1052) [cytosol] (R-MMU-202829) PTK2(1-772) [cytosol] (R-MMU-202827) PTK2 [cytosol] (R-MMU-201621) phospho-p-Y397-PTK2 [cytosol] (R-MMU-354068) phospho-p-6Y-PTK2 [cytosol] (R-MMU-354128)	0.589	2
UniProt:Q00959 Grin2a	3	Grin2a [plasma membrane] (R-RNO-6794271) Grin2a [endoplasmic reticulum membrane] (R-RNO-9609845) p-Y-Grin2a [plasma membrane] (R-RNO-9628245)	0.558	4
UniProt:Q01973 ROR1	2	ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727) ROR1 [plasma membrane] (R-HSA-197814)	0.544	2
UniProt:Q9CQV6	3	Map1lc3b [autophagosome membrane] (R-MMU-5683641) Map1lc3b [cytosol] (R-MMU-5682674) Map1lc3b [cytosol] (R-MMU-5205651)	0.528	2
UniProt:O70469	1	Dok2 [cytosol] (R-MMU-204823)	0.524	3
UniProt:P70315 Was	1	Wasp [cytosol] (R-MMU-2029026)	0.524	2
UniProt:P07141 Csf1	4	Csf1 [extracellular region] (R-MMU-9680617) Csf1 [extracellular region] (R-MMU-9009484) phospho-Csf1 [endoplasmic reticulum lumen] (R-MMU-8956881) Csf1 [endoplasmic reticulum lumen] (R-MMU-8956778)	0.524	2
UniProt:P23242 Gja1	7	p-S373-Gja1 [plasma membrane] (R-MMU-9857672) Gja1 [Golgi membrane] (R-MMU-190649) Gja1 [endoplasmic reticulum membrane] (R-MMU-190654) Gja1 [lysosomal membrane] (R-MMU-196173) phospho-Gja1 [plasma membrane] (R-MMU-191657) Gja1 [plasma membrane] (R-MMU-9857668) Gja1 [Golgi-associated vesicle membrane] (R-MMU-190544)	0.499	3
UniProt:P31750 Akt1	12	phospho-p-T308,S473-AKT1 [nucleoplasm] (R-MMU-198357) phospho-p-T308,S473-AKT1 [cytosol] (R-MMU-198356) phospho-p-S473-AKT1 [plasma membrane] (R-MMU-377265) AKT1 [plasma membrane] (R-MMU-199416) AKT1 [cytosol] (R-MMU-58252) phospho-p-T308-AKT1 [cytosol] (R-MMU-198634) phospho-p-Y315,Y326-AKT1 [cytosol] (R-MMU-8848757) phospho-p-T308,S473-AKT1 [plasma membrane] (R-MMU-199430) p-T308,S473-Akt1 [cytosol] (R-MMU-162346) Akt1 [cytosol] (R-MMU-189709) phospho-p-S473-AKT1 [cytosol] (R-MMU-9841264) p-T308,S473-Akt1 [plasma membrane] (R-MMU-1445123)	0.499	3
UniProt:Q63767	4	phospho-Bcar1 [cytosol] (R-RNO-372645) phospho-Bcar1 [cytosol] (R-RNO-5218739) phospho-Bcar1 [cytosol] (R-RNO-8848723) Bcar1 [cytosol] (R-RNO-201625)	0.471	2
UniProt:P54763 Ephb2	9	phospho-p-Y596,Y602-EPHB2 [plasma membrane] (R-MMU-3928375) p-Ephb2 [plasma membrane] (R-MMU-3928433) EPHB2 [plasma membrane] (R-MMU-443809) EPHB2 (19-?) [extracellular region] (R-MMU-3928436) EPHB2 (?-1055) [plasma membrane] (R-MMU-3928386) EPHB2 (?-1055) [cytosol] (R-MMU-3928432) P54763 [plasma membrane] (R-MMU-3928394) Ephb2 [plasma membrane] (R-MMU-3928443) p-Y604,Y610-Ephb2 [plasma membrane] (R-MMU-4093312)	0.463	3
UniProt:P35546 Ret	3	Ret [plasma membrane] (R-MMU-9830456) RET [plasma membrane] (R-MMU-8853797) phospho-p-5Y-RET [plasma membrane] (R-MMU-8854162)	0.463	2
UniProt:P35438 Grin1	3	Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.462	2

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