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SQSTM1 [cytosol]
Stable Identifier
R-MMU-193937
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q64337
Locations in the PathwayBrowser
Expand all
Autophagy (Mus musculus)
Macroautophagy (Mus musculus)
Selective autophagy (Mus musculus)
Mitophagy (Mus musculus)
PINK1-PRKN Mediated Mitophagy (Mus musculus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle] (Mus musculus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Mus musculus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Mus musculus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
p62 binds ubiquitinated mitochondrial substrates (Mus musculus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
p62 links damaged mitochondria to LC3 (Mus musculus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Mus musculus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
Pexophagy (Mus musculus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B [peroxisomal membrane] (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B [peroxisomal membrane] (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
KEAP1-NFE2L2 pathway (Mus musculus)
SQSTM1 oligomerizes (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
SQSTM1 oligomer [cytosol] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
TRIM21 ubiquitinates SQSTM1 (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
p62:MEKK3 binds to TRAF6 (Mus musculus)
MAP3K3:SQSTM1 [cytosol] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Mus musculus)
MAP3K3:SQSTM1 [cytosol] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Cell death signalling via NRAGE, NRIF and NADE (Mus musculus)
NRIF signals cell death from the nucleus (Mus musculus)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
Polyubiquitinated NRIF migrates to the nucleus (Mus musculus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
p75NTR signals via NF-kB (Mus musculus)
NF-kB is activated and signals survival (Mus musculus)
IKKbeta is activated (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
p75NTR recruits signalling complexes (Mus musculus)
IKK-beta is recruited (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
TRAF6 is auto-ubiquitinated (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
p62 is recruited and forms a complex with TRAF6 (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
p62 recruits an atypical PKC (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
SQSTM1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q64337
Reference Genes
BioGPS Gene:18412
ENSEMBL:ENSMUSG00000015837
KEGG:mmu:18412
Monarch:18412
NCBI Gene:18412
UCSC:Q64337
Reference Transcript
RefSeq:NM_001290769.1
RefSeq:NM_011018.3
Other Identifiers
101995_at
10385572
130488_f_at
138538_at
1442726_s_at
1444021_at
1450957_a_at
17262300
18412
4386396
4418662
4451479
4452757
4628906
4680302
4682782
5033026
5070108
5128089
5240762
5293633
5301227
5349242
5520468
5592894
5608712
A_55_P2069714
A_66_P110606
GE111305
GE35850
GO:0000122
GO:0000407
GO:0000423
GO:0000425
GO:0000932
GO:0001659
GO:0001934
GO:0002376
GO:0002931
GO:0003712
GO:0005080
GO:0005515
GO:0005634
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005776
GO:0005783
GO:0005829
GO:0006351
GO:0006355
GO:0006366
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0007005
GO:0007032
GO:0008270
GO:0010508
GO:0012501
GO:0016234
GO:0016235
GO:0016236
GO:0016605
GO:0019899
GO:0019901
GO:0030017
GO:0030154
GO:0030163
GO:0030674
GO:0031397
GO:0031410
GO:0031625
GO:0034144
GO:0035255
GO:0035591
GO:0035973
GO:0038023
GO:0042169
GO:0042802
GO:0043122
GO:0043130
GO:0043226
GO:0043231
GO:0043232
GO:0044753
GO:0044754
GO:0044877
GO:0045202
GO:0046872
GO:0060089
GO:0060090
GO:0061635
GO:0070342
GO:0070530
GO:0071211
GO:0097009
GO:0097225
GO:0097413
GO:0098780
GO:0098978
GO:0110076
GO:0140036
GO:0140110
GO:0140311
GO:0140313
GO:0140693
GO:0140694
GO:1900273
GO:1903078
GO:1905719
ILMN_2710705
mMC023176
u40930_s_at
Participates
as an input of
TRIM21 ubiquitinates SQSTM1 (Mus musculus)
SQSTM1 oligomerizes (Mus musculus)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Mus musculus)
p62 is recruited and forms a complex with TRAF6 (Mus musculus)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Mus musculus)
p62 binds ubiquitinated mitochondrial substrates (Mus musculus)
as a component of
SQSTM1 oligomer [cytosol] (Mus musculus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
MAP3K3:SQSTM1 [cytosol] (Mus musculus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Mus musculus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Mus musculus)
Other forms of this molecule
K7 ub-SQSTM1 [cytosol]
phospho-p-S349 SQSTM1 [cytosol]
phospho-ub K420 p-S349 SQSTM1 [cytosol]
SQSTM1 [nucleoplasm]
Inferred From
SQSTM1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_035148.1
,
NP_001277698.1
ENSEMBL
ENSMUSP00000099835
,
ENSMUST00000102774
,
ENSMUST00000015981
,
ENSMUSP00000015981
PRO
Q64337
GlyGen
Q64337
MGI
107931
PDB
2ZJD
,
3ADE
,
2RRU
,
3WDZ
,
3B0F
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
0.698
6
UniProt:Q9Z2X8
3
Keap1 [cytosol]
(R-MMU-976038)
Keap1 [cytosol]
(R-MMU-9766647)
Keap1 [cytosol]
(R-MMU-6782766)
0.65
6
UniProt:P62991 UBIQ
0.573
3
UniProt:P48281
2
polySUMO2-VDR [nucleoplasm]
(R-MMU-4546376)
VDR [nucleoplasm]
(R-MMU-375512)
0.471
3
UniProt:P28700 Rxra
5
RXRA [cytosol]
(R-MMU-9619757)
phospho-p-S21-RXRA [nucleoplasm]
(R-MMU-5334811)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-MMU-4341130)
Rxra [nucleoplasm]
(R-MMU-442483)
RXRA [nucleoplasm]
(R-MMU-381319)
0.471
3
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