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Axin1 [cytosol]
Stable Identifier
R-MMU-195249
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
AXIN1, O35625
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by WNT (Mus musculus)
Degradation of beta-catenin by the destruction complex (Mus musculus)
AXIN is phosphorylated in the destruction complex (Mus musculus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
Assembly of the destruction complex (Mus musculus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
TCF dependent signaling in response to WNT (Mus musculus)
Degradation of AXIN (Mus musculus)
AXIN is ubiquitinated by SMURF2 (Mus musculus)
AXIN:SMURF2 [cytosol] (Mus musculus)
AXIN [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
SMURF2 binds AXIN (Mus musculus)
AXIN [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
AXIN:SMURF2 [cytosol] (Mus musculus)
AXIN [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
Tankyrase ADP-ribosylates AXIN (Mus musculus)
AXIN:TNKS [cytosol] (Mus musculus)
AXIN [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
Tankyrase binds AXIN (Mus musculus)
AXIN [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
AXIN:TNKS [cytosol] (Mus musculus)
AXIN [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Mus musculus)
Beta-catenin is released from the destruction complex (Mus musculus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
GSK3B:AXIN1 [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Mus musculus)
GSK3B:AXIN1 [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Mus musculus)
GSK3B:AXIN1 [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Mus musculus)
GSK3B:AXIN1 [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Mus musculus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Mus musculus)
GSK3B:AXIN1 [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Mus musculus)
GSK3B:AXIN1 [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Mus musculus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [early endosome membrane] (Mus musculus)
GSK3B:AXIN1 [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Mus musculus)
GSK3B:AXIN1 [cytosol] (Mus musculus)
Axin1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O35625 Axin1
Gene Names
Axin1, Axin, Fu
Chain
chain:1-863
Reference Genes
BioGPS Gene:12005 Axin1
KEGG Gene (Mus musculus):12005 Axin1
Monarch:12005 Axin1
NCBI Gene:12005 Axin1
Reference Transcript
RefSeq:NM_009733.2 Axin1
Participates
as an input of
Assembly of the destruction complex (Mus musculus)
as a member of
AXIN [cytosol] (Mus musculus)
as a component of
GSK3B:AXIN1 [cytosol] (Mus musculus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Other forms of this molecule
Phospho Axin1 [cytosol]
Axin1 [cytosol]
phospho-Axin1 [cytosol]
phospho-Axin1 [cytosol]
Axin1 [cytosol]
Phospho (3 sites) Axin1 [cytosol]
phospho-Axin1 [cytosol]
Inferred From
AXIN1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_033863.2
PRO
O35625
MGI
1096327
PDB
3UTM
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q02248 Ctnnb1
12
phospho-Ctnnb1 [nucleoplasm]
(R-MMU-3134926)
phospho-Ctnnb1 [cytosol]
(R-MMU-3134933)
Ctnnb1 [cytosol]
(R-MMU-202950)
Ctnnb1 [cytosol]
(R-MMU-202930)
Ctnnb1 [nucleoplasm]
(R-MMU-3451168)
Ctnnb1 [cytosol]
(R-MMU-448839)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942374)
beta-catenin [cytosol]
(R-MMU-206225)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942369)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942367)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942363)
Ctnnb1 [plasma membrane]
(R-MMU-9038440)
0.725
9
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.688
4
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.659
5
UniProt:P98078
3
Dab2 [cytosol]
(R-MMU-8862456)
Dab2 [lysosomal membrane]
(R-MMU-2980807)
Dab2 [plasma membrane]
(R-MMU-2980808)
0.656
4
UniProt:O75581 LRP6
8
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6N [extracellular region]
(R-HSA-5334021)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
LRP6 [plasma membrane]
(R-HSA-206252)
0.589
2
UniProt:Q9WV60 Gsk3b
3
GSK3beta [cytosol]
(R-MMU-206095)
Gsk3b [nucleoplasm]
(R-MMU-182565)
Gsk3b [cytosol]
(R-MMU-2997551)
0.589
2
UniProt:Q99ML9 Rnf111
3
Rnf111 [cytosol]
(R-MMU-975981)
Rnf111 [nucleoplasm]
(R-MMU-2186735)
Rnf111 [nucleoplasm]
(R-MMU-2186765)
0.581
4
UniProt:O95271 TNKS
1
TNKS [cytosol]
(R-HSA-3640825)
0.581
4
UniProt:O88572
5
Lrp6 [early endosome membrane]
(R-MMU-5368481)
phospho-Lrp6 [early endosome membrane]
(R-MMU-5368496)
phospho-Lrp6 [plasma membrane]
(R-MMU-1458894)
phospho-Lrp6 [plasma membrane]
(R-MMU-1458895)
Lrp6 [plasma membrane]
(R-MMU-206252)
0.527
5
UniProt:P46937 YAP1
7
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
YAP1 [cytosol]
(R-HSA-1253345)
YAP1 [nucleoplasm]
(R-HSA-1253322)
0.524
3
UniProt:Q61062
4
Dvl3 [cytosol]
(R-MMU-4652688)
Dvl3 [cytosol]
(R-MMU-201678)
phospho-Dvl3 [cytosol]
(R-MMU-201680)
phospho-Dvl3 [cytosol]
(R-MMU-3772400)
0.499
2
UniProt:Q9EPK5 Wwtr1
4
Wwtr1 [nucleoplasm]
(R-MMU-2064930)
phospho-Wwtr1 [cytosol]
(R-MMU-2028665)
Wwtr1 [cytosol]
(R-MMU-1629773)
Wwtr1 [nucleoplasm]
(R-MMU-1629775)
0.499
4
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