Reactome | Irs1 [cytosol]

Irs1 [cytosol]

Stable Identifier

R-MMU-198257

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Insulin receptor substrate-1, IRS1_MOUSE

External Reference Information

External Reference

UniProt:P35569 Irs1

Gene Names

Irs1, Irs-1

Chain

chain:1-1233

Reference Genes

BioGPS Gene:16367 Irs1

KEGG:mmu:16367 Irs1

Monarch:16367 Irs1

NCBI Gene:16367 Irs1

UCSC:P35569 Irs1

Reference Transcript

RefSeq:NM_010570.4 Irs1

Participates

as a component of

(bNTF3:p-5Y-Ntrk3 homodimer,bNTF3:p-5Y-Ntrk3 homodimer:MyrG-p-Y424-Src):Irs1 [plasma membrane] (Bos taurus)

as an input of

Activated Ntrk3 binds Irs1 (Mus musculus)

as a member of

Irs1,2 [cytosol] (Mus musculus)

Other forms of this molecule

p-Irs1 [cytosol]

phospho-Irs1 [plasma membrane]

Irs1 [plasma membrane]

Phospho-IRS1 (by NTRK1) [cytosol]

Irs1 [cytosol]

phospho-Irs1 [cytosol]

phospho-Irs1 [plasma membrane]

Cross References

RefSeq

NP_034700.2

PRO

P35569

GlyGen

P35569

MGI

99454

PDB

1AYB, 5AXI

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26450 Pik3r1	5	p-Y-Pik3r1 [cytosol] (R-MMU-9680631) Pik3r1 [cytosol] (R-MMU-3080572) Pi3k-p85 alpha [cytosol] (R-MMU-1295777) Pik3r1 [cytosol] (R-MMU-74789) Pik3r1 [plasma membrane] (R-MMU-198365)	0.702	3
UniProt:P09405	1	Ncl [nucleoplasm] (R-MMU-6791213)	0.581	3
UniProt:Q1XH17 Trim72	1	Trim72 [cytoplasmic vesicle membrane] (R-MMU-5333009)	0.576	4
UniProt:Q9CQV8 Ywhab	1	14-3-3 beta/alpha [cytosol] (R-MMU-1445100)	0.527	2
UniProt:Q13625-2 TP53BP2			0.524	2
UniProt:P67778	2	Phb1 [mitochondrial inner membrane] (R-MMU-8953720) Phb1 [cytosol] (R-MMU-5672944)	0.462	2
UniProt:Q76MZ3 Ppp2r1a	2	Ppp2r1a [nucleoplasm] (R-MMU-165968) PP2A A subunit [cytosol] (R-MMU-206067)	0.462	2
UniProt:P10922	1	H1-0 [nucleoplasm] (R-MMU-206132)	0.462	2
UniProt:Q02248 Ctnnb1	14	Ctnnb1 [nucleoplasm] (R-MMU-3451168) Ctnnb1 [cytosol] (R-MMU-448839) Ctnnb1 [cytosol] (R-MMU-202930) Ctnnb1 [cytosol] (R-MMU-202950) Ctnnb1 [nucleoplasm] (R-MMU-9735212) Ctnnb1 [plasma membrane] (R-MMU-9038440) Ctnnb1 [plasma membrane] (R-MMU-9761458) phospho-Ctnnb1 [cytosol] (R-MMU-8942374) beta-catenin [cytosol] (R-MMU-206225) phospho-Ctnnb1 [cytosol] (R-MMU-8942369) phospho-Ctnnb1 [cytosol] (R-MMU-8942367) phospho-Ctnnb1 [cytosol] (R-MMU-8942363) phospho-Ctnnb1 [cytosol] (R-MMU-3134933) phospho-Ctnnb1 [nucleoplasm] (R-MMU-3134926)	0.462	2

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