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phospho-p-T308,S473-AKT1 [nucleoplasm]
Stable Identifier
R-MMU-198357
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
P31750
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Regulation of beta-cell development (Mus musculus)
Regulation of gene expression in beta cells (Mus musculus)
AKT-mediated inactivation of FOXO1A (Mus musculus)
AKT phosphorylates FOXO1A (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
FOXO-mediated transcription (Mus musculus)
Regulation of localization of FOXO transcription factors (Mus musculus)
AKT phosphorylates FOXO transcription factors (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Activity through Acetylation (Mus musculus)
AKT phosphorylates KAT6A (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
KAT6A and PML bind TP53 (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
Regulation of TP53 Activity through Association with Co-factors (Mus musculus)
AKT phosphorylates PHF20 (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
FLT3 Signaling (Mus musculus)
AKT phosphorylates FOXO3 downstream of FLT3 (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
AKT phosphorylates targets in the nucleus (Mus musculus)
AKT can phosphorylate NR4A1 (NUR77) (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
AKT can phosphorylate RSK (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
AKT phosphorylates CREB1 (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
AKT phosphorylates FOXO transcription factors (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Mus musculus)
AKT phosphorylates CREB1 (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
Signaling by WNT (Mus musculus)
TCF dependent signaling in response to WNT (Mus musculus)
Deactivation of the beta-catenin transactivating complex (Mus musculus)
AKT phosphorylates CBY1 (Mus musculus)
p-AKT1/2 [nucleoplasm] (Mus musculus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:P31750 Akt1
Gene Names
Akt1, Akt, Rac
Chain
chain:1-480
Reference Genes
BioGPS Gene:11651 Akt1
KEGG:mmu:11651 Akt1
Monarch:11651 Akt1
NCBI Gene:11651 Akt1
UCSC:P31750 Akt1
Reference Transcript
RefSeq:NM_001165894.1 Akt1
RefSeq:NM_001331107.1 Akt1
RefSeq:XM_006515415.1 Akt1
RefSeq:NM_009652.3 Akt1
Other Identifiers
100970_at
10402766
11651
1416657_at
1425711_a_at
1440950_at
17284201
4452681
4621781
4647742
4676071
4698638
4743247
4745929
4764800
4785406
4800631
4828773
4857592
4926349
5095531
5096643
5098101
5158236
5164502
5261716
5297798
5302822
5438177
5447423
5568831
5615111
A_51_P237553
A_52_P418014
A_55_P2066384
A_66_P107415
GE35054
GO:0001649
GO:0001893
GO:0001938
GO:0002042
GO:0003013
GO:0003376
GO:0003824
GO:0004672
GO:0004674
GO:0004712
GO:0005080
GO:0005515
GO:0005516
GO:0005524
GO:0005547
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005758
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005975
GO:0005977
GO:0005978
GO:0005979
GO:0006006
GO:0006091
GO:0006355
GO:0006412
GO:0006417
GO:0006468
GO:0006606
GO:0006886
GO:0006913
GO:0006915
GO:0006924
GO:0006954
GO:0006974
GO:0006979
GO:0007005
GO:0007010
GO:0007173
GO:0007249
GO:0007281
GO:0007399
GO:0008286
GO:0008289
GO:0008637
GO:0009408
GO:0009725
GO:0010467
GO:0010507
GO:0010595
GO:0010628
GO:0010629
GO:0010748
GO:0010763
GO:0010765
GO:0010907
GO:0010918
GO:0010975
GO:0012501
GO:0015630
GO:0016020
GO:0016301
GO:0016567
GO:0016740
GO:0019049
GO:0019899
GO:0019901
GO:0021510
GO:0022414
GO:0022605
GO:0030030
GO:0030154
GO:0030163
GO:0030235
GO:0030291
GO:0030307
GO:0030334
GO:0030335
GO:0031397
GO:0031641
GO:0031663
GO:0031982
GO:0031999
GO:0032094
GO:0032287
GO:0032436
GO:0032794
GO:0032869
GO:0032880
GO:0032929
GO:0032991
GO:0033138
GO:0034405
GO:0034614
GO:0035556
GO:0035655
GO:0035924
GO:0036064
GO:0036294
GO:0038061
GO:0042593
GO:0042802
GO:0042803
GO:0042981
GO:0043065
GO:0043066
GO:0043154
GO:0043161
GO:0043226
GO:0043325
GO:0043491
GO:0043536
GO:0045429
GO:0045600
GO:0045725
GO:0045792
GO:0045861
GO:0045893
GO:0045907
GO:0045944
GO:0046326
GO:0046329
GO:0046622
GO:0046889
GO:0048009
GO:0048266
GO:0048661
GO:0048856
GO:0048870
GO:0051146
GO:0051247
GO:0051721
GO:0060416
GO:0060709
GO:0060716
GO:0061024
GO:0070141
GO:0070848
GO:0071260
GO:0071276
GO:0071356
GO:0071363
GO:0071364
GO:0071380
GO:0071407
GO:0071456
GO:0071889
GO:0072655
GO:0072656
GO:0090201
GO:0097011
GO:0097194
GO:0098772
GO:0098978
GO:0099104
GO:0099175
GO:0106310
GO:0110002
GO:0110099
GO:0120283
GO:0140052
GO:0140096
GO:0150033
GO:0160049
GO:1900087
GO:1900182
GO:1901653
GO:1902018
GO:1903038
GO:1903078
GO:1903715
GO:1904263
GO:1905552
GO:1990090
GO:1990418
GO:2000010
GO:2000402
GO:2001243
ILMN_1213935
mMC023289
x65687_s_at
Participates
as a member of
p-AKT1/2 [nucleoplasm] (Mus musculus)
p-T,p-S-AKT [nucleoplasm] (Mus musculus)
Other forms of this molecule
phospho-p-T308,S473-AKT1 [cytosol]
phospho-p-S473-AKT1 [plasma membrane]
AKT1 [plasma membrane]
AKT1 [cytosol]
phospho-p-T308-AKT1 [cytosol]
phospho-p-Y315,Y326-AKT1 [cytosol]
phospho-p-T308,S473-AKT1 [plasma membrane]
p-T308,S473-Akt1 [cytosol]
Akt1 [cytosol]
phospho-p-S473-AKT1 [cytosol]
p-T308,S473-Akt1 [plasma membrane]
Inferred From
p-T308,S473-AKT1 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 308
Coordinate
308
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 473
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001159366.1
,
XP_006515478.1
,
NP_001318036.1
,
NP_033782.1
ENSEMBL
ENSMUST00000001780
,
ENSMUSP00000001780
ZINC - Substances
AKT1_MOUSE
ZINC target
P31750
PRO
P31750
ZINC - Predictions - Purchasable
AKT1_MOUSE
MGI
87986
GlyGen
P31750
HMDB Protein
HMDBP13418
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8K4K2 Trib3
3
Trib3 [nucleoplasm]
(R-MMU-9644304)
Trib3 [cytosol]
(R-MMU-162411)
Trib3 [plasma membrane]
(R-MMU-199447)
0.625
5
UniProt:P48678 Lmna
0.564
2
UniProt:Q1W6H9 F110C
0.537
3
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.525
3
UniProt:P62991 UBIQ
0.524
3
UniProt:P05480 Src
13
SRC-2 [cytosol]
(R-MMU-191648)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-MMU-1810408)
SRC-1 [plasma membrane]
(R-MMU-65043)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-MMU-377598)
phospho-p-Y419-SRC [cytosol]
(R-MMU-377592)
Src [cytosol]
(R-MMU-418782)
phospho-p-Y419-SRC-1 [plasma membrane]
(R-MMU-112331)
MyrG-SRC [plasma membrane]
(R-MMU-8876922)
phospho-p-Y419-SRC [cytosol]
(R-MMU-8964276)
SRC [cytosol]
(R-MMU-9628701)
MyrG-p-Y424-Src [plasma membrane]
(R-MMU-9011258)
Activated Src [nucleoplasm]
(R-MMU-8937700)
p-Y416-Src [cytosol]
(R-MMU-8964306)
0.499
3
UniProt:Q8TCU6 PREX1
1
PREX1 [cytosol]
(R-HSA-8863083)
0.499
2
UniProt:Q9R1E0 Foxo1
6
phospho-Foxo1 [nucleoplasm]
(R-MMU-5692651)
Ac-K242,K245,K262-Foxo1 [nucleoplasm]
(R-MMU-9626941)
phospho-Foxo1 [cytosol]
(R-MMU-211158)
phospho-Foxo1 [nucleoplasm]
(R-MMU-199306)
Foxo1 [nucleoplasm]
(R-MMU-187293)
Foxo1 [nucleoplasm]
(R-MMU-199300)
0.462
4
UniProt:Q8BUB4 WDFY2
0.462
4
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