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PI3K alpha [cytosol]
Stable Identifier
R-MMU-198379
Type
Complex
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
RET signaling (Mus musculus)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GPVI-mediated activation cascade (Mus musculus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)
PI3K alpha, beta, gamma [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
CD28 co-stimulation (Mus musculus)
CD28 dependent PI3K/Akt signaling (Mus musculus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
CD28:PI3K [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PI3K binds CD28 (Mus musculus)
CD28:PI3K [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PI3K binds ICOS (Mus musculus)
ICOS:PI3K [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-2 family signaling (Mus musculus)
Interleukin receptor SHC signaling (Mus musculus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
14-3-3 zeta binding allows recruitment of PI3K (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Interleukin receptor SHC signaling (Mus musculus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Regulation of signaling by CBL (Mus musculus)
CBL ubiquitinates PI3K (Mus musculus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Mus musculus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
CD28:PI3K [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
ICOS:PI3K [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
CD28:PI3K [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
ICOS:PI3K [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
RAC1,RAC2,RHOG activate PI3K (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (q) signalling events (Mus musculus)
G alpha (q) inhibits PI3K alpha (Mus musculus)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
PI3K binds membrane-associated estrogen receptors (Mus musculus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PTK2 is recruited to methylated ESR1 (Mus musculus)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Mus musculus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by SCF-KIT (Mus musculus)
Direct recruitment of PI3K to p-KIT (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase cycle (Mus musculus)
RAC1 GTPase cycle (Mus musculus)
RAC1 binds effectors at the plasma membrane (Mus musculus)
RAC1 effectors [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
RAC1:GTP:RAC1 effectors [plasma membrane] (Mus musculus)
RAC1 effectors [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
RAC2 GTPase cycle (Mus musculus)
RAC2 binds effectors at the plasma membrane (Mus musculus)
RAC2 plasma membrane effectors [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Mus musculus)
RAC2 plasma membrane effectors [cytosol] (Mus musculus)
PI3K alpha [cytosol] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
PI3K-regulatory subunits [cytosol]
(Mus musculus)
Pik3ca [cytosol]
(Mus musculus)
Participates
as a member of
RAC2 plasma membrane effectors [cytosol] (Mus musculus)
RAC1 effectors [cytosol] (Mus musculus)
p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
PI3K alpha, beta, gamma [cytosol] (Mus musculus)
as an input of
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)
PI3K binds membrane-associated estrogen receptors (Mus musculus)
G alpha (q) inhibits PI3K alpha (Mus musculus)
PI3K binds CD28 (Mus musculus)
RAC1,RAC2,RHOG activate PI3K (Mus musculus)
PI3K binds ICOS (Mus musculus)
Direct recruitment of PI3K to p-KIT (Mus musculus)
as a component of
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Mus musculus)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Mus musculus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Mus musculus)
ICOS:PI3K [plasma membrane] (Mus musculus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Mus musculus)
CD28:PI3K [plasma membrane] (Mus musculus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Mus musculus)
Inferred From
PI3K alpha [cytosol]
(Homo sapiens)
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