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PRKN [cytosol]
Stable Identifier
R-MMU-201579
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q9WVS6
Locations in the PathwayBrowser
Expand all
Autophagy (Mus musculus)
Macroautophagy (Mus musculus)
Selective autophagy (Mus musculus)
Aggrephagy (Mus musculus)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Mus musculus)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Mus musculus)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
Parkin binds Ub:UBE2N:UBE2V1 (Mus musculus)
PRKN [cytosol] (Mus musculus)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
Parkin transfers Ub to misfolded proteins (Mus musculus)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Mus musculus)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Mus musculus)
UBE2N:UBE2V1:PRKN [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Mus musculus)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Mus musculus)
UBE2N:UBE2V1:PRKN [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
UBE2N:UBE2V1:PRKN [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Mus musculus)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Mus musculus)
UBE2N:UBE2V1:PRKN [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Mus musculus)
UBE2N:UBE2V1:PRKN [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
Mitophagy (Mus musculus)
PINK1-PRKN Mediated Mitophagy (Mus musculus)
PINK1 phosphorylates PRKN at S65 (Mus musculus)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Mus musculus)
PRKN [cytosol] (Mus musculus)
PRKN binds p-S-Ub:MOM proteins (Mus musculus)
PRKN [cytosol] (Mus musculus)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Mus musculus)
PRKN [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
Polyubiquitination of substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
Release of E3 from polyubiquitinated substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Josephin domain DUBs (Mus musculus)
ATXN3 deubiquitinates polyUb-PARK2 (Mus musculus)
ATXN3:PARK2 [cytosol] (Mus musculus)
PRKN [cytosol] (Mus musculus)
PARK2 autoubiquitinates (Mus musculus)
PRKN [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9WVS6
Reference Genes
BioGPS Gene:50873
ENSEMBL:ENSMUSG00000023826
ENSEMBL:ENSMUSG00000023826.18
KEGG Gene (Mus musculus):50873
Monarch:50873
NCBI Gene:50873
UCSC:Q9WVS6
Reference Transcript
RefSeq:NM_001317726.1
RefSeq:NM_016694.4
Other Identifiers
102073_at
10441718
140453_g_at
1420755_a_at
1426135_a_at
1449975_a_at
17333206
4326707
4334955
4342637
4452040
4460959
4583915
4607877
4716013
4751870
5031918
5050779
50873
5154000
5252416
5307034
5480781
5515070
5573744
A_52_P327073
A_52_P342940
A_52_P636038
A_55_P1978226
A_55_P2055379
A_55_P2745124
GE36993
GO:0000122
GO:0000139
GO:0000151
GO:0000209
GO:0000266
GO:0000422
GO:0000423
GO:0001664
GO:0001933
GO:0001963
GO:0001964
GO:0003714
GO:0003779
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0006351
GO:0006355
GO:0006511
GO:0006513
GO:0006807
GO:0006914
GO:0006979
GO:0007005
GO:0007010
GO:0007612
GO:0007626
GO:0008013
GO:0008021
GO:0008092
GO:0008270
GO:0008344
GO:0009056
GO:0010498
GO:0010506
GO:0010628
GO:0010629
GO:0010636
GO:0010637
GO:0010821
GO:0010918
GO:0010994
GO:0012501
GO:0014069
GO:0015631
GO:0016020
GO:0016192
GO:0016235
GO:0016567
GO:0016607
GO:0016740
GO:0019538
GO:0019899
GO:0019900
GO:0019901
GO:0023052
GO:0030154
GO:0030163
GO:0030165
GO:0030424
GO:0030544
GO:0030672
GO:0031072
GO:0031396
GO:0031410
GO:0031624
GO:0031625
GO:0031647
GO:0031648
GO:0032232
GO:0032436
GO:0032991
GO:0034976
GO:0035249
GO:0035774
GO:0036211
GO:0042053
GO:0042415
GO:0042417
GO:0042802
GO:0042826
GO:0042981
GO:0042995
GO:0043005
GO:0043025
GO:0043065
GO:0043123
GO:0043130
GO:0043161
GO:0043195
GO:0043226
GO:0043274
GO:0043524
GO:0043653
GO:0044238
GO:0044828
GO:0044877
GO:0045202
GO:0045944
GO:0046329
GO:0046676
GO:0046872
GO:0046928
GO:0048471
GO:0048856
GO:0050804
GO:0050821
GO:0050877
GO:0051087
GO:0051582
GO:0051583
GO:0051646
GO:0051865
GO:0051881
GO:0051967
GO:0055086
GO:0061024
GO:0061630
GO:0061734
GO:0065003
GO:0070050
GO:0070534
GO:0070585
GO:0070842
GO:0070936
GO:0070979
GO:0071704
GO:0085020
GO:0090090
GO:0090141
GO:0090201
GO:0090258
GO:0090394
GO:0097237
GO:0097602
GO:0097708
GO:0098691
GO:0098779
GO:0098793
GO:0098794
GO:0098978
GO:0099072
GO:0099073
GO:0099074
GO:0140096
GO:0140110
GO:0140251
GO:1900242
GO:1900407
GO:1901135
GO:1901526
GO:1901800
GO:1902236
GO:1902254
GO:1902530
GO:1903265
GO:1903377
GO:1903382
GO:1903427
GO:1903542
GO:1903599
GO:1903861
GO:1904049
GO:1904881
GO:1905232
GO:1905366
GO:1905477
GO:1990381
GO:1990444
GO:1990452
GO:2000377
GO:2000378
GO:2001171
ILMN_1216086
ILMN_1240999
ILMN_2645955
ILMN_2773073
ILMN_2773074
mMC005219
mMC021448
mMR029335
Participates
as a component of
ATXN3:PARK2 [cytosol] (Mus musculus)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Mus musculus)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Mus musculus)
UBE2N:UBE2V1:PRKN [cytosol] (Mus musculus)
as an input of
PARK2 autoubiquitinates (Mus musculus)
PRKN binds p-S-Ub:MOM proteins (Mus musculus)
Parkin binds Ub:UBE2N:UBE2V1 (Mus musculus)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Other forms of this molecule
polyUb-PARK2 [cytosol]
phospho-p-S9-PRKN [cytosol]
phospho-p-S65-PRKN [cytosol]
Inferred From
PRKN [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001304655.1
,
NP_057903.1
Ensembl
ENSMUSP00000140587
,
ENSMUST00000191124
,
ENSMUSG00000023826
PRO
Q9WVS6
MGI
1355296
PDB
3B1L
,
2ZEQ
,
1MG8
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6IQX7-2 CHPF
0.488
3
UniProt:P47811 Mapk14
7
MAPK14 [secretory granule lumen]
(R-MMU-6803300)
MAPK14 [extracellular region]
(R-MMU-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-MMU-6803280)
MAPK14 [nucleoplasm]
(R-MMU-446223)
MAP kinase p38 alpha [cytosol]
(R-MMU-448843)
phospho-MAP kinase p38 alpha [cytosol]
(R-MMU-448842)
p-T180,Y182-Mapk14 [nucleoplasm]
(R-MMU-1605486)
0.463
3
UniProt:Q99MQ3 Pink1
6
Pink1 [cytosol]
(R-MMU-9621285)
PINK1(111-581) [mitochondrial intermembrane space]
(R-MMU-5205628)
PINK1 [cytosol]
(R-MMU-5205637)
PINK1 [mitochondrial intermembrane space]
(R-MMU-5205671)
PINK1 [mitochondrial outer membrane]
(R-MMU-5205653)
phospho-p-S228,S402-PINK1 [mitochondrial outer membrane]
(R-MMU-9834051)
0.463
2
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