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ACVR2B [plasma membrane]
Stable Identifier
R-MMU-201656
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
P27040
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by Activin (Mus musculus)
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Mus musculus)
ACVR2A,B [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Mus musculus)
ACVR2A,B [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane] (Mus musculus)
ACVR2A,B [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Mus musculus)
ACVR2A,B [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Mus musculus)
ACVR2A,B [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Mus musculus)
Activin:ACVR2A,B:p-ACVR1B,C [plasma membrane] (Mus musculus)
Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane] (Mus musculus)
ACVR2A,B [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
Activin AB,B:ACVR2A,B:p-ACVR1C [plasma membrane] (Mus musculus)
ACVR2A,B [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
Signaling by BMP (Mus musculus)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Mus musculus)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Mus musculus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Mus musculus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Mus musculus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
BMP2 binds to the receptor complex (Mus musculus)
BMP:BMPRII:BMPRI [plasma membrane] (Mus musculus)
BMPRII:BMPRI [plasma membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
BMPRII:BMPRI [plasma membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
Formation of a heteromeric BMP receptor complex (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
BMPRII:BMPRI [plasma membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Mus musculus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Mus musculus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
I-Smad competes with R-Smad1/5/8 for type I receptor (Mus musculus)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Mus musculus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
Phospho-R-Smad1/5/8 dissociates from the receptor complex (Mus musculus)
BMP:p-BMPR:Endofin [early endosome membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
Type II receptor phosphorylates type I receptor (Mus musculus)
BMP:BMPRII:BMPRI [plasma membrane] (Mus musculus)
BMPRII:BMPRI [plasma membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Mus musculus)
BMPRII dimer [plasma membrane] (Mus musculus)
Type II receptor [plasma membrane] (Mus musculus)
ACVR2B [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:P27040 Acvr2b
Gene Names
Acvr2b
Chain
signal peptide:1-18, chain:19-536
Reference Genes
BioGPS Gene:11481 Acvr2b
ENSEMBL:ENSMUSG00000061393.15 Acvr2b
KEGG Gene (Mus musculus):11481 Acvr2b
Monarch:11481 Acvr2b
NCBI Gene:11481 Acvr2b
UCSC:P27040 Acvr2b
Reference Transcript
RefSeq:NM_001313757.1 Acvr2b
RefSeq:NM_007397.3 Acvr2b
RefSeq:XM_006511926.3 Acvr2b
Other Identifiers
10590169
11481
1419140_at
1439856_at
17523081
4329415
4330550
4538383
4706726
4785135
4952188
5022444
5058133
5302263
5320171
5336616
5490741
5549194
5557300
5563434
93903_at
A_52_P422618
A_55_P2012815
A_65_P12695
GE34720
GO:0000122
GO:0000166
GO:0001501
GO:0001702
GO:0001822
GO:0001946
GO:0001974
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0004712
GO:0005515
GO:0005524
GO:0005737
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0007165
GO:0007178
GO:0007368
GO:0007389
GO:0007498
GO:0007507
GO:0009749
GO:0009791
GO:0009952
GO:0009966
GO:0016020
GO:0016301
GO:0016310
GO:0016362
GO:0016740
GO:0017002
GO:0019209
GO:0019838
GO:0023052
GO:0030073
GO:0030154
GO:0030324
GO:0030501
GO:0030509
GO:0031016
GO:0032924
GO:0032927
GO:0032991
GO:0034711
GO:0035265
GO:0036211
GO:0042475
GO:0043235
GO:0045669
GO:0046872
GO:0048179
GO:0048185
GO:0048617
GO:0048705
GO:0048856
GO:0060021
GO:0060089
GO:0060836
GO:0060840
GO:0060841
GO:0061298
GO:0071363
GO:0098772
GO:0120163
GO:0140096
ILMN_1230145
Msa.403.0_at
Msa.403.0_g_at
mMC004278
Participates
as a member of
Type II receptor [plasma membrane] (Mus musculus)
ACVR2A,B [plasma membrane] (Mus musculus)
Other forms of this molecule
Acvr2b (ActRIIB) [plasma membrane]
Inferred From
ACVR2B [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_006511989.1
,
NP_001300686.1
,
NP_031423.1
Ensembl
ENSMUSP00000035093
,
ENSMUSP00000150566
,
ENSMUST00000035093
,
ENSMUSP00000126108
,
ENSMUSG00000061393
,
ENSMUST00000165044
,
ENSMUST00000215746
PRO
P27040
MGI
87912
PDB
2H64
,
1S4Y
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P36896 ACVR1B
2
ACVR1B [plasma membrane]
(R-HSA-205867)
p-4S,T188,T206-ACVR1B [plasma membrane]
(R-HSA-205780)
0.499
4
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