Reactome | Grap2 [cytosol]

Grap2 [cytosol]

Stable Identifier

R-MMU-202367

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

GRAP2, O89100

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Regulation of T cell activation by CD28 family (Mus musculus)
    - Co-stimulation by CD28 (Mus musculus)
      - Gads binds CD28 (Mus musculus)
        
        CD28:GRAP2 [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
  - TCR signaling (Mus musculus)
    - Generation of second messenger molecules (Mus musculus)
      - Disassociation of PLC-gamma1 from SLP-76 (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Phosphorylation of PLC-gamma1 (Mus musculus)
        
        PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Mus musculus)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        Phosphorylated PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Mus musculus)
        
        phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Mus musculus)
        
        ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Phosphorylation of SLP-76 (Mus musculus)
        
        SLP-76 bound to Gads:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Recruitment of Gads to LAT (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Recruitment of ITK to SLP-76 (Mus musculus)
        
        ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Recruitment of PLC-gamma1 to SLP-76 (Mus musculus)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Recruitment of SLP-76 to Gads (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        SLP-76 bound to Gads:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
- Cytokine Signaling in Immune system (Mus musculus)
  - FLT3 Signaling (Mus musculus)
    - Active FLT3 binds to GRAP2 (Mus musculus)
      - Grap2 [cytosol] (Mus musculus)
      - active FLT3:GRAP2 [plasma membrane] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
- Innate Immune System (Mus musculus)
  - DAP12 interactions (Mus musculus)
    - DAP12 signaling (Mus musculus)
      - Activation of RAC1 by VAV2/3 (Mus musculus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Phosphorylation of BTK by p-SYK (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-SYK/p-BTK [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Phosphorylation of SLP-76 by p-SYK (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Release of p-PLCG1 (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
  - Fc epsilon receptor (FCERI) signaling (Mus musculus)
    - FCERI mediated Ca+2 mobilization (Mus musculus)
      - Autophosphorylation of BTK/ITK (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Hydrolysis of PIP2 by PLCG (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Phosphorylation of TEC kinases by p-SYK (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
    - FCERI mediated MAPK activation (Mus musculus)
      - Activation of RAC1 by VAV (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Autophosphorylation of PAK (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Phosphorylation and activation of VAV (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Phosphorylation of SLP-76 by p-SYK (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Recruitment of PAK to the membrane by binding active RAC1 (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
      - Recruitment of VAV to p-SLP-76 (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        Grap2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:O89100 Grap2

Gene Names

Grap2, Gads, Grb2l, Grid, Mona

Chain

chain:1-322

Reference Genes

BioGPS Gene:17444 Grap2

KEGG:mmu:17444 Grap2

Monarch:17444 Grap2

NCBI Gene:17444 Grap2

UCSC:O89100 Grap2

Reference Transcript

Other Identifiers

102633_at

10425410

1420685_at

1460280_at

17313147

17444

4364713

4459336

4495518

4580470

4652221

4662234

4782509

4899922

4994215

5087101

5181111

5205719

5260784

5277011

5280997

5334482

5537125

5586648

A_52_P120612

A_52_P150683

GE119100

GO:0001784

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0007165

GO:0031410

GO:0043226

GO:0043408

ILMN_1218749

ILMN_2711241

ILMN_2711242

ILMN_3113787

mMC007464

mMC021078

Participates

as an input of

as a component of

as a member of

Adapter proteins [cytosol] (Mus musculus)

Other forms of this molecule

Grap2 [cytosol]

Inferred From

GRAP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_034945.1, NP_001276371.1

ENSEMBL

ENSMUSP00000155681, ENSMUSP00000046532, ENSMUSG00000042351, ENSMUST00000043149, ENSMUST00000229980

PRO

O89100

MGI

1333842

PDB

1OEB, 1H3H, 2D0N, 1R1S, 1R1P, 1R1Q, 1UTI, 2W10

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.835	7
UniProt:P40818 USP8	2	p-T945-USP8 [cytosol] (R-HSA-1358714) USP8 [cytosol] (R-HSA-917720)	0.75	4
UniProt:Q9QUN3	2	Blnk [cytosol] (R-MMU-912750) phospho-Blnk [plasma membrane] (R-MMU-983579)	0.658	4
UniProt:Q6PB44 PTN23			0.618	3
UniProt:O35601 Fyb	2	Adap [cytosol] (R-MMU-430207) Fyb1 [cytosol] (R-MMU-390925)	0.611	3
UniProt:Q8WV28 BLNK	2	BLNK [cytosol] (R-HSA-912750) p-5Y-BLNK [plasma membrane] (R-HSA-983579)	0.609	2
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.602	3
UniProt:P70218 M4K1			0.558	2
UniProt:Q80U87	2	Usp8 [cytosol] (R-MMU-917720) phospho-Usp8 [cytosol] (R-MMU-1358714)	0.544	4
UniProt:Q60787 Lcp2	2	SLP-76 [cytosol] (R-MMU-430203) phospho-Lcp2 [cytosol] (R-MMU-202175)	0.499	7
UniProt:P09581 Csf1r	5	p-Y559-Csf1r [plasma membrane] (R-MMU-9763882) PolyUb,p-8Y-Csf1r [plasma membrane] (R-MMU-9680640) K48polyUb,p-Y559-Csf1r [plasma membrane] (R-MMU-9763897) Csf1r [plasma membrane] (R-MMU-9680626) CSF1R [plasma membrane] (R-MMU-197667)	0.482	2

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