Glce epimerises GlcA to IdoA

Stable Identifier
R-MMU-2024090
Type
Reaction [transition]
Species
Mus musculus
Compartment
Golgi membrane, Golgi lumen
ReviewStatus
5/5
General
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Glce epimerises GlcA to IdoA
The enzyme glucuronyl C5-epimerase (Glce) mediates the epimerisation of GlcA to IdoA and has been characterised in mouse (Li et al. 2001, Crawford et al. 2001).
Literature References
PubMed ID Title Journal Year
11274177 Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate

Li, JP, Gong, F, Jalkanen, M, Lindahl, U, El Darwish, K

J Biol Chem 2001
11279150 Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase

Crawford, BE, Pinhal, MA, Esko, JD, Olson, SK

J Biol Chem 2001
Participants
Input
Output
Catalyst Activity

UDP-glucuronate 5'-epimerase activity of Glce [Golgi membrane]

Physical Entity
Glce [Golgi membrane] (Mus musculus)
Activity
UDP-glucuronate 5'-epimerase activity (GO:0050379)
Orthologous Events
GLCE epimerises more GlcA to IdoA as sulfate content rises (Homo sapiens)
GLCE epimerises GlcA to IdoA (Homo sapiens)
Authored
Jassal, B  (2011-12-14)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-12-14)
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