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About
What is Reactome ?
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Team
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Our Logo
License Agreement
Privacy Notice
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Digital Preservation
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Table of Contents
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phospho-p-S177,S181-IKBKB [cytosol]
Stable Identifier
R-MMU-202506
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
O88351
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Downstream signaling events of B Cell Receptor (BCR) (Mus musculus)
Activation of NF-kappaB in B cells (Mus musculus)
Activated IKK phosphorylates I-kappaB (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
Activation of IKK complex (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of NEMO by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
IKBA is phosphorylated by Phospho IKKB kinase (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Interleukin-17 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of NEMO by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Cytosolic sensors of pathogen-associated DNA (Mus musculus)
ZBP1(DAI) mediated induction of type I IFNs (Mus musculus)
RIP-mediated NFkB activation via ZBP1 (Mus musculus)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Mus musculus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Mus musculus)
TRAF6 mediated NF-kB activation (Mus musculus)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Mus musculus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated NF-kB activation (Mus musculus)
Phosphorylation of IKK-beta by TAK1 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of NEMO by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
SLC15A4:TASL-dependent IRF5 activation (Mus musculus)
Activated IKBKB phosphorylates IRF5 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
SLC15A4:TASL-dependent IRF5 activation (Mus musculus)
Activated IKBKB phosphorylates IRF5 (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
CHUK, IKBKB phosphorylate CYLD at S418 (Mus musculus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Mus musculus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Mus musculus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Mus musculus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
p75NTR signals via NF-kB (Mus musculus)
NF-kB is activated and signals survival (Mus musculus)
IKKbeta is activated (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
Phospho-IKK-beta homdimer [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
Phospho-IKK-beta homdimer [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
Phospho-IKK-beta homdimer [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O88351
Reference Genes
BioGPS Gene:16150
ENSEMBL:ENSMUSG00000031537
KEGG:mmu:16150
Monarch:16150
NCBI Gene:16150
UCSC:O88351
Reference Transcript
RefSeq:NM_010546.2
Participates
as a component of
Phospho-IKK-beta homdimer [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
Other forms of this molecule
IKBKB [cytosol]
Inferred From
p-S177,S181-IKBKB [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 177 (in Homo sapiens)
Coordinate
177
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 181 (in Homo sapiens)
Coordinate
181
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_034676.1
ZINC - Substances
IKKB_MOUSE
ZINC target
O88351
PRO
O88351
GlyGen
O88351
MGI
1338071
ZINC - Predictions - Purchasable
IKKB_MOUSE
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O88522
5
IKBKG [cytosol]
(R-MMU-168108)
Ub-285-IKBKG [cytosol]
(R-MMU-741397)
K63polyUb-IKBKG [cytosol]
(R-MMU-202530)
IKBKG [nucleoplasm]
(R-MMU-4755413)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-MMU-4755449)
0.896
8
UniProt:Q60680
4
phospho-p-Y187,Y198-CHUK [cytosol]
(R-MMU-9861501)
phospho-p-T23-CHUK [cytosol]
(R-MMU-198615)
phospho-p-S176,S180-CHUK [cytosol]
(R-MMU-177667)
CHUK [cytosol]
(R-MMU-168104)
0.656
4
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.508
2
UniProt:P01375 TNF
5
TNF(1-233) [plasma membrane]
(R-HSA-66220)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
0.499
3
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