Reactome | K63polyUb-IKBKG [cytosol]

K63polyUb-IKBKG [cytosol]

Stable Identifier

R-MMU-202530

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

O88522

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O88522

Reference Genes

BioGPS Gene:16151

ENSEMBL:ENSMUSG00000004221

ENSEMBL:ENSMUSG00000004221.17

KEGG Gene (Mus musculus):16151

Monarch:16151

NCBI Gene:16151

UCSC:O88522

Reference Transcript

Other Identifiers

103216_f_at

10600453

106513_at

114642_at

1421209_s_at

1435646_at

1435647_at

1450161_at

1454690_at

16151

17535877

4351254

4361674

4377973

4536196

4656738

4666587

4683716

4696993

4744405

4776859

4811573

4901553

4916474

4973696

5001324

5124760

5186378

5195279

5211541

5228344

5452504

5454553

5488773

94196_at

AA198384_at

A_51_P260300

A_51_P380201

A_51_P423404

A_52_P156110

A_52_P507853

A_55_P2050652

GE35594

GO:0000151

GO:0000922

GO:0001782

GO:0002376

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0006351

GO:0006355

GO:0006914

GO:0006974

GO:0008385

GO:0010628

GO:0012501

GO:0016239

GO:0019904

GO:0023052

GO:0031593

GO:0031625

GO:0032991

GO:0035591

GO:0042742

GO:0042802

GO:0042803

GO:0042975

GO:0043123

GO:0043226

GO:0043276

GO:0044877

GO:0045944

GO:0046872

GO:0046982

GO:0050862

GO:0051092

GO:0051650

GO:0060090

GO:0065003

GO:0070530

GO:0072686

GO:0098542

GO:1902236

GO:1990450

GO:1990459

ILMN_1220188

ILMN_2598585

ILMN_2630423

ILMN_2698097

mMC003436

mMR030958

Participates

as a member of

K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Mus musculus)

as a component of

CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)

Other forms of this molecule

monoSUMO1-K277,K309-IKBKG [nucleoplasm]

IKBKG [cytosol]

Ub-285-IKBKG [cytosol]

IKBKG [nucleoplasm]

Inferred From

K63polyUb-IKBKG [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 321 (in Homo sapiens)

Coordinate

321

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 325 (in Homo sapiens)

Coordinate

325

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 326 (in Homo sapiens)

Coordinate

326

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_006527915.1, XP_011245829.1, XP_006527913.1, NP_034677.2, XP_006527914.1, NP_001154895.1

Ensembl

ENSMUST00000164101, ENSMUSP00000109763, ENSMUSP00000109762, ENSMUST00000114127, ENSMUSP00000109768, ENSMUST00000114128, ENSMUSP00000126770, ENSMUSG00000004221, ENSMUST00000114133

PRO

O88522

MGI

1338074

PDB

3F89, 2ZVN, 2ZVO, 4OWF, 3JSV, 2V4H

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O88351	2	phospho-p-S177,S181-IKBKB [cytosol] (R-MMU-202506) IKBKB [cytosol] (R-MMU-168114)	0.896	8
UniProt:Q60680	3	phospho-p-T23-CHUK [cytosol] (R-MMU-198615) phospho-p-S176,S180-CHUK [cytosol] (R-MMU-177667) CHUK [cytosol] (R-MMU-168104)	0.85	6
IntAct:EBI-4399559 UBIQ			0.71	5
UniProt:P62991 UBIQ			0.676	3
UniProt:Q924T7	1	RNF31 [cytosol] (R-MMU-5212660)	0.623	7
UniProt:O88522	5	monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-MMU-4755449) IKBKG [cytosol] (R-MMU-168108) Ub-285-IKBKG [cytosol] (R-MMU-741397) K63polyUb-IKBKG [cytosol] (R-MMU-202530) IKBKG [nucleoplasm] (R-MMU-4755413)	0.592	2
UniProt:P24772 PG200			0.499	2

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