Reactome | Dctn6 [cytosol]

Dctn6 [cytosol]

Stable Identifier

R-MMU-2029035

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

DCTN6, Q9WUB4

Locations in the PathwayBrowser

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Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Mus musculus)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)
      - Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - MHC class II antigen presentation (Mus musculus)
    - Transport of antigen loaded MHC II molecules to surface (Mus musculus)
      - Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)
      - Kinesins:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPI-mediated anterograde transport (Mus musculus)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPI-mediated anterograde transport (Mus musculus)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Mus musculus)
    - Golgi-to-ER retrograde transport (Mus musculus)
      - COPI-independent Golgi-to-ER retrograde traffic (Mus musculus)
        
        Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)
        
        RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Mus musculus)
        
        Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn6 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9WUB4

Gene Names

Dctn6

Reference Genes

BioGPS Gene:22428 Dctn6

ENSEMBL:ENSMUSG00000031516

ENSEMBL:ENSMUSG00000031516.12 Dctn6

KEGG Gene (Mus musculus):22428 Dctn6

Monarch:22428 Dctn6

NCBI Gene:22428 Dctn6

UCSC:Q9WUB4 Dctn6

Reference Transcript

Other Identifiers

10578138

1416499_a_at

1448368_at

160327_at

17508706

22428

4422117

4592896

4788022

5180509

5249659

5460655

5526289

5608536

A_55_P2001228

A_66_P123954

GE36283

GO:0000278

GO:0000775

GO:0000776

GO:0003824

GO:0005694

GO:0005737

GO:0005739

GO:0005813

GO:0005815

GO:0005856

GO:0005869

GO:0006629

GO:0007005

GO:0007010

GO:0007052

GO:0008610

GO:0043226

GO:0070840

ILMN_1233586

aa217493_s_at

mMC000822

Participates

as a component of

Pointed end complex [cytosol] (Mus musculus)

Inferred From

DCTN6 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_035852.1, NP_001280688.1, NP_001280687.1, NP_001280686.1

Ensembl

ENSMUSP00000033913, ENSMUSG00000031516, ENSMUST00000033913

PRO

Q9WUB4

MGI

1343154

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